英文别名: TBK1 (TANK-Binding Kinase 1, NFkB Activating Kinase, NAK, T2K) (HRP)中文名: 中文别名: CBNumber: CB04944647 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 1 TBK1 (TANK-Binding Kinase 1, NFkB Activating Kinase, NAK, T2K) (HRP)化学性质...
1. Delhase M, Kim SY, Lee H, Naiki-Ito A, Chen Y, Ahn ER, Murata K, Kim SJ, Lautsch N, Kobayashi KS, Shirai T, Karin M, Nakanishi M. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 2012 Jan 24...
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1.利用KO细胞系证明TRAF3在RNA和DNA通路中的作用 有相关研究表明肿瘤坏死因子(TNF)受体相关因子3 (TRAF3)在RNA途径中介导IFN的激活中发挥重要作用。从机制上讲，TRAF3与RNA通路中的适配器IPS-1有关，驱动信号激活到TBK1-IRF3信号轴。Kislay等从其他研究者那里获取到关键敲除细胞系（Traf2−/−、Sting−/−...
SECTM1A SECTM1B STING/TMEM173 TBK1 TSPAN6 USP11 USP4 VCP Ubiquitin Array Kit Ubiquitin Array Kit Related Information Apoptosis Catalog 2010 (PDF 5MB) Cytokine-related Mechanisms of Apoptosis Human Cell Stress Array IL-1 Family The Multiple Functions of IL-33 Transcription Factors and Regul...
Scroll over each target protein for more information ATM (P-Ser1981) eIF-2a (P-Ser52) HDAC2 (P-Ser394) HDAC4 (P-Ser632) IKB-alpha (P-Ser32) MSK1 (P-Ser376) NF-kB (P-Ser536) STAT1 (P-Ser727) TAK1 (P-Ser412) TBK1 (P-Ser172) ...
(c-IAP2), FADD, IRAK1, IRAK2, IRF1, MYD88, RIPK1, TBK1, TICAM1 (TRIF), TNFAIP3, TRADD, TRAF2, TRAF3, TRAF6. Cytoplasmic Sequestering/Releasing of NFκB: BCL3, CHUK (IKKa), IKBKB, IKBKG, NFKBIA, NFKBIE. Transcription Factors: NFKB1, NFKB2, REL, RELA, RELB. NFκB Responsive...
此外,作者通过过表达p65/RelA来激活NF-κB信号,发现通过Etop、TG或ST的凋亡诱导在报告的检测中极大地抑制了p65诱导的NF-κB-luc活性(图3B)和p65诱导的细胞因子的产生(图3C)。此外,与以前的研究一致,TBK1或IRF3诱导的ISRE-luc活性也被凋亡诱导所抑制(图3B)。这些数据表明,细胞凋亡通过caspase-3抑制NF-κB信号。
Kinases: RIPK1, TBK1. Other: BCL10, BIRC2 (c-IAP2), NOD1 (CARD4), CASP1 (ICE), CASP8 (FLICE), CFLAR (CASPER), FADD, IKBKE, MALT1, PPM1A, REL, TRIM13 (RFP2), TRADD. NFκB Responsive Genes: Extracellular and Adhesion Molecules: AGT, CSF1 (MCSF), CSF2 (GM-CSF), CSF3 (...
The IKK-related kinase, TBK1, shares 65% similarity to IKKɛ. Bcl3, B-cell lymphoma 3; HLH, helix-loop-helix; IκB, inhibitor of NF-κB; NBD, NEMO-binding domain; SS, conserved serines in IκB; ULD, ubiquitin-like domain. The canonical NF-κB transcription factor is a dimer ...