摘要 NF-kBinducing kinase (NIK), which is essential for the activation of the noncanonical NF-kB pathway, regulates diverse processes in immunity, development, and disease. Although recent studies have elucidated important functions of NIK in adaptive immune cells and cancer cell metabolism, the rol...
It was found that RIP2 activates NFkB pathway and up-regulates the anti-apoptotic ability of BNHL cells, providing experimental basis for its function in tumorigenesis and development. Keywords: RIP2, NFkB pathway, BNHL cells, anti-apoptosis 细胞凋亡是一种程序性的细胞死亡过程,对于维持组织稳态和...
Inthisstudy,weexploredthemechanismbywhichRIP2regulatesNFkBpathwaytopromoteanti-apoptosisinBNHLcells.ItwasfoundthatRIP2activatesNFkBpathwayandup-regulatestheanti-apoptoticabilityofBNHLcells,providingexperimentalbasisforitsfunctionintumorigenesisanddevelopment.Keywords:RIP2,NFkBpathway,BNHLcells,anti-apoptosis细胞凋亡...
Moreover, atypical protein kinase (aPKC) has been shown to play a novel role in modulating the NF‐kB pathway. In this review, I focus on neurons and the factors that contribute to regulation of NF‐kB via aPKC. J. Neurosci. Res. 58:607–611, 1999. ? 1999 Wiley‐Liss, Inc. 展开...
Target genes of the NFkB cellular signaling pathway are disclosed, which are associated with a cellular function such as cell division, apoptosis or protection against oxidative stress of an active NFkB cellular signaling pathway and can be used for determining a cellular function of an active NF...
Request a print copy of NFKB Signaling Pathway poster Nuclear factor kappa beta (NFkB) is a nearly ubiquitous pathway responsible for mediating DNA transcription, and therefore cell function. The pathway is activated by a variety of stimuli including cellular stress, cytokines, free radicals, UV ...
Function : Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Promotes proteolytic processing of NFKB2/P100, which leads to activation of NF-kappa-B via the non-canonical pathway. Could act in a receptor-sel...
Overexpression or knockdown models of PRMT5 and E2F-1 were constructed, and pharmacological intervention with NF -KB was determine the function of the PRMT5/E2F-1/NF-KB pathway in myocardial hypertrophy. Results shows that PRMT5 was down-regulated in the TAC rat model as well as in an in-...
influence its function in up-regulating NF-κB pathway, hydroxyphenylpyruvic acid(HPP), the substrate of HPD, and homogentisic acid(HGA), the product of HPD, had little influence on NF-κB pathway. These results indicate HPD up-regulates NF- κB pathway independent of its enzyme activity....
Together, these results indicate that ASIC1a protein expression and channel function are closely regulated by the activity of protein kinase C and its downstream signaling pathway(s).doi:10.1007/s12035-020-02056-4Ling ZhangTian-Dong LengTao Yang...