The aim of this study was to assess NF-kB activation/localization in canine mammary gland tumors (CMGT) on tissues developed in nude mice by transplantation of two different CMGT cell lines and those surgically removed from CMGT patients.Lobna Mkaouar...
2 NF-KB信号通路NF_KB介导的信号通路足一个抗凋亡的信号通路,经典的NF_KB信号通路如下:未激活的NF-KB以二聚体的形式存在 于细胞质中,与KB抑制分子(inhibitors of KB,IKBs)结合,掩盖 了NF-KB中的核定位序列(nuclear localization sequence, NLS),阻止NF-KB向核移位。研究发现所有的激活NF-KB的 信号通路都通过...
NF-kB protein dimmers as nuclear transcription factor, they need to migrate to the nucleus, combined with DNA to have function. In most types of the normal cells under resting state, NF-KB was inactive and retain in the cytoplasm. They binding to a specific inhibitors called IK-B protein,...
IkB覆盖于NFkB的核定位信号区(nuclear localization sequence, NLS),使之以无活性形式存在于胞浆中。细胞受到活 化信号刺激后,由活化信号诱导激活的IkB激酶(IkB Kinase, IkK)引起IkBQ蛋白第32和36位丝氨酸的磷酸化,磷酸 化的IkBa则由泛素蛋白在多个位点形成泛素化。最后,泛 素化的IkBa被26S蛋白酶水解降解,暴露...
This results in the exposure of the nuclear localization signals (NLS) on NF-kB subunits and the subsequent translocation of the molecule to the nucleus. In the nucleus, NF-kB binds with a consensus sequence (5'GGGACTTTCC-3') of various genes and thus activates their transcription. IkB ...
which is followed by its ubiquitination and subsequent degradation. This results in the exposure of the nuclear localization signals (NLS) on NF-kB subunits and the subsequent translocation of the molecule to the nucleus. In the nucleus, NF-kB binds with a consensus sequence (5'GGGACTTTCC-3'...
Iκ B 覆盖于 NF κB 的核定位信号区( nuclear localization sequence , NLS ),使之以无活性形式存在于胞浆中。细胞受到活化信号刺激后,由活化信号诱导激活的 Iκ B 激酶( Iκ B Kinase, Iκ K)引起 I κ B α 蛋白第 32 和 36 位丝氨酸的磷酸化,磷酸化的 I κ B α则由泛素蛋白在多个位点形成...
NF-κB为一个转录因子蛋白家族,包括5个亚单位:Rel (cRel)、p65 (RelA, NF-κB3)、RelB和p50(NF-κB1)、p52(NF-κB2).p65 、cRel和RelB分含有N端Rel同源区(Rel homology domain, RHD)和C端的反式激活结构域(transactivation domain, TD),在RHD的C末端有一个核定位区域(nuclear-localization sequence,...
(p50) is a 50KDa functional sub-unit of NF-kB and a member of Rel protein family which is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains. NFKB1 (p50) forms homodimers ...
(p50) is a 50KDa functional sub-unit of NF-kB and a member of Rel protein family which is synthesized as a p105 precursor protein and consists of an N-terminal conserved RHD-region containing nuclear localization signal, DNA-binding and dimerization domains. NFKB1 (p50) forms homodimers ...