Also cells engineered to inhibit expression and/or function of NFAT/AP-1 pathway are provided. Disclosed cells are T and NK cells. It can be expanded to create homogeneous or heterogenous cell populations and/or combined with pharmaceutically acceptable carriers. It can be CAR cells. Methods to...
The data from luciferase assays indicate that K15 expression in BJAB cells induced NFAT and AP1 activities. The tyrosine residue in the C-terminal end of K15 required for the Lyn interaction appeared to be essential for NFAT/AP1 activation, highlighting the significance of the C-terminal SH2B ...
The Wiskott-Aldrich syndrome (WAS) is a severe imunodeficiency caused by mutation in the WASP gene. T-cells from WAS patients and WASP deficient (-/-) mice are unable to proliferate or secrete IL-2 after antiCD3 stimulation. The IL-2 promoter is activated by NF-AT, AP1 and NF-kB. ...
板井 昭子WO2003103647A1 * 2003年6月5日 2003年12月18日 Inst Med Molecular Design Inc Inhibitors against the activation of ap-1 and nfatWO2003103647A1 2003年6月5日 2003年12月18日 Inst Med Molecular Design Inc Inhibitors against the activation of ap-1 and nfat...
Glycyrrhizic acid and 18beta-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1,CRE and NFAT activation[J].{H}PHYTOMEDICINE,2013,(3/4):295-302.Kao TC, Wu CH, Yen GC. (2013). Glycyrrhizic acid and 18beta-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-...
ALTERATIONS IN THE ACTIVITIES OF T CELL NUCLEAR FACTORS, NFAT AND AP1, AFTER BURN INJURYcord bloodcord-blood bankingstem cellstransplantationDKMSAn abstract is unavailable. This article is available as a PDF only.doi:10.1097/00024382-199906001-00214Mao, H....