The IL-2 promoter is activated by NF-AT, AP1 and NF-kB. To investigate the role of WASP in the activation of these transcription factors, we analyzed their expression in splenocytes from WASP-/- mice and wild type (WT) controls. Methods WASP-/- and WT splenocytes were stimulated ...
NFATC proteins bind DNA efficiently in partnership with such factors as AP1, GATA4, FOXP and MEF2. NFATC3 was first suggested to be involved in chondrogenesis downstream of calcineurin in a limb bud mesenchymal cell assay in vitro [61]. In vivo, NFATC1 was detected in superficial ACCs and...
需要金币:*** 金币(10金币=人民币1元) 针对NFAT信号途径的新型免疫抑制剂.pdf 关闭预览 想预览更多内容,点击免费在线预览全文 免费在线预览全文 ISSN 中国生物化学与分子生物学报 2008 年 5 月 CN 113870Q Chinese Journal of Biochemistry and Molecular Biology 24 (5) :391～397 ·综述 · 针对 NFAT 信号...
Ets-1 has been found to physically interact with several nuclear proteins, including NFAT, AP1, and STAT5 =-=(23, 42, 43)-=-, which can modulate the activity of Ets-1. The physical interaction between Ets-1 and T-bet may be too weak to be detected by coimmunoprecipitation. We would...
According to previous studies, the signaling pathways that regulate cell stem functions mainly include Ca2+[18], TGF-β [19], c-MYC[20], RAS/ERK[21], NF-kB [22], Hippo-YAP1 [23], JAK/STAT [24], Notch [25], [26], PI3K/AKT[27], and Wnt/β-Catenin pathway [28]. Activation...
Hyperproliferation and dysregulation of IL-4 expression in NF-ATp-deficient mice Immunity, 4 (1996), pp. 1-20 View in ScopusGoogle Scholar 16 T. Hoey, Y-L. Sun, K. Williamson, X. Xu Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT ...
Of the putative NFAT binding sites, 4 were conserved between mouse and human, 3 within the 5′ 245 bp of the 1.3 kb promoter, and 1 which comprises an NFAT;AP1 composite consensus site. We therefore sought to ascertain if the RANKL-induction of the human β3 promoter was mediated by ...
This finding using NFATc3-GFP is consistent with previous work demonstrating a requirement for AKAP79/150-CaN anchoring in LTCC activation of endogenous NFATc4 (Li et al., 2012, Oliveria et al., 2007). Download: Download high-res image (774KB) Download: Download full-size image Figure ...