2022年10月,浙江大学医学院附属妇产科医院张丹教授团队在Nature子刊Nature Communications上发文:BNC1 deficiency-triggered ferroptosis through the NF2-YAP pathway induces primary ovarian insufficiency。文章中,作者通过建立Basonuclin 1 (BNC1...
Hippo pathway and ferroptosis (Fig.4h, i). Since mitochondria-mediated lipid peroxidation is crucial in ferroptosis31,32and the Hippo pathway promotes ferroptosis20,33, these findings indicated that ferroptosis might be involved in the process ofBnc1mutation leading to POI. Fig. 4:Bnc1mutation may...
The NF2/P-YAP signaling pathway was identified as a downstream effector of miR-92a-3p, influencing the expression of ACSL4/GPX4 and IL-6, with the expression of these genes being enhanced following taurine supplementation. Clinically, taurine levels in CSF exhibited a negative correlation with IL...
In epithelial cells, such interactions mediated by E-cadherin suppress ferroptosis by activating the intracellular NF2 (also known as merlin) and Hippo signalling pathway. Antagonizing this signalling axis allows the proto-oncogenic transcriptional co-activator YAP to promote ferroptosis by upregulating ...
KAT2B inhibits CCA cell growth via interaction with SP1 to promote the expression of NF2 and thus activate Hippo pathway, which leads to subsequent inhibition of the oncogenic YAP signaling. **P < 0.01 Full size image SP1 is a zinc finger transcription factor which binds to GC-rich ...
Multiple Merlin/NF2 effector pathways including the Hippo-YAP/TAZ pathway have been identified. However, the molecular mechanisms underpinning the growth and survival of NF2-mutant tumors remain poorly understood. Using an inducible orthotopic kidney tumor model, we demonstrate that YAP/TAZ silencing is...
Recently the tumor suppressor neurofibromatosis 2 (Nf2) was shown to regulate the balance of neural progenitor proliferation and differentiation in the developing mouse brain through the Hippo pathway effectors, transcriptional coactivators Yap/Taz. The molecular mechanism of how Nf2 regulates Yap/Taz is...
Aim To investigate the prophylactic efficacy of gut microbiota-based treatments on nonalcoholic steatohepatitis (NASH) management via modulation of Hippo signaling pathway-related genes (YAP1, LATS1 and NF2), and their epigenetic regulators (miR-1205 and lncRNA SRD5A3-AS1) retrieved from in-silico...
We further show that Nf2 functions by inhibiting the Yap/Taz transcriptional coactivators, probably through a mechanism that is distinct from the canonical Hippo pathway. Overexpressing human YAP in NPCs causes a hippocampal malformation phenotype that closely resembles that of Nf2 mutants and, ...
In epithelial cells, such interactions mediated by E-cadherin suppress ferroptosis by activating the intracellular NF2 (also known as merlin) and Hippo signalling pathway. Antagonizing this signalling axis allows the proto-oncogenic transcriptional co-activator YAP to promote ferroptosis by upregulating ...