(CCLE), CIBERSORT, Human Protein Atlas (HPA), and cBioPortal, we employed various bioinformatics methods to explore the role of NF2 in pan-cancer, including analyzing the association between NF2 and tumor diagnosis, prognosis, immune cell infiltration, tumor mutational burden (TMB), and ...
NF2andLATS2 Regarding cooccurringNF2and large tumor suppressor 2 (LATS2) mutations, Tranchant et al. defined a new molecular subgroup of MPM, named the C2LN. C2LNis characterized by a cooccurring mutation in theLATS2andNF2genes and is associated with a poor prognosis. Interestingly, this sub...
Molecular changes in Mesothelioma with an impact on prognosis and treatment (2) Deletions and point mutations of the NF2 gene on 22q12 are frequently found in perineuriomas, but this finding can be seen in schwannomas and several other solid tumors. Perineurioma: a distinctive and underrecogniz...
Molecular Genetic Analysis of Ependymal Tumors : NF2 Mutations and Chromosome 22q Loss Occur Preferentially inIntramedullary Spinal EpendymomasEpendymal tumors are heterogeneous with regard to morphology, localization, age at first clinical manifestation, and prognosis. Several molecular alterations have been ...
Cholangiocarcinoma (CCA) is a highly malignant cancer of the biliary tract with poor prognosis. Further mechanistic insights into the molecular mechanisms of CCA are needed to develop more effective target therapy. The expression of the histone lysine ac
For example, upregulation of SNHG5 is found in hepatocellular carcinoma (HCC) and may be associated with HCC prognosis30. Over-expression of SNHG5 contributes to the promotion of proliferation, migration and metastasis in cancer cells31. Notably, SNHG5 has also been found to be involved in...
Also, in recent years, several classifications based on integrated molecular analyses have been proposed and have indicated that the prognosis of patients with meningiomas with NF2 variant/22q loss ranges from good to poor. In addition, these studies have suggested that a more accurate prognosis ...
Background/Objectives: With the rise in prevalence of diagnostic genetic techniques like RNA sequencing and whole exome sequencing (WES), as well as biological treatment regiments for cancer therapy, several genes have been implicated in carcinogenesis.
结论:血栓性疾病患者血D-二聚体明显升高,它是血栓性疾病的一个理想监测指标.%Objective:Dynamically observe the serum D-dimer level of patients wit h thrombus, for instructing drug therapy and judging prognosis.Methods: Detect serum D-dimer level by latex agglutination in 113 cases, among these 20 ...
Histiocytoses are rare disorders of unknown origin with highly heterogeneous prognosis. BRAFV600E gain-of-function mutations have been observed in 57% of cases of Langerhans cell histiocytosis (LCH) and 54% of cases of Erdheim-Chester di... Drier,Aurelie,Hervier,... - 《Blood》 被引量: 43...