A third of patients with paraganglial tumors, pheochromocytoma, and paraganglioma, carry germline mutations in one of the susceptibility genes, RET, VHL, NF1, SDHAF2, SDHA, SDHB, SDHC, SDHD, TMEM127, and MAX. Despite increasing importance, data for long-term prognosis are scarce in ...
However, a substantial proportion of cancer patients still respond poorly to immunotherapy4, 5. Of note, tumors undergo genetic alterations to elude the immune systems, largely undermining therapeutic efficacy6. Therefore, clarifying the molecular determinants that govern the immune evasion of cancers is...
Cutaneous metastasis (CM) accounts for 5–30% of patients with breast cancer (BC) and presents unfavorable response to treatment and poor prognosis. A better understanding of the molecular alterations involved in metastasis is essential, which would help
Cutaneous metastasis (CM) accounts for 5–30% of patients with breast cancer (BC) and presents unfavorable response to treatment and poor prognosis. A better understanding of the molecular alterations involved in metastasis is essential, which would help
Multivariate analysis showed the proportion of bone marrow blasts ≥65.4% was a factor significantly affecting OS in PTPN11 mut patients (p = 0.043). Keywords: acute myeloid leukemia; PTPN11 mutations; prevalence; clinical characteristics; prognosis 1 Introduction Acute myeloid leukemia (AML) is a ...
Suppression of emotions, particularly anger, in breast cancer patients has been identified as a behavioural risk factor. With the refinement of histopathological techniques in breast cancer prognosis there have been no attempts to correlate these two measures. Scores on the Cortauld Emotional Control Sc...
Compared with patients with MET amplification, patients in the negative control (NC) group had a significantly better OS (P = 0.022) after PSM. Analysis of 1661 pancancer cases with the MSK-IMPACT assay showed that patients receiving immunotherapy in the MET ...
1b). These results suggest that focal CNVs are the major genomic alterations of ACGEJ in Chinese patients. Fig. 1: Featured ACGEJ genomic and transcriptomic changes. a Frequencies of CNVs detected in 124 ACGEJ samples, with gains in red and losses in blue. Bars represent non-overlapped 1-...
Based on the IARC database (R20),TP53is the most common mutated gene in human cancers, nearly mutated in 50% of cancer patients. Among these, colorectal, esophageal, lung, and pancreas cancers, as well as head and neck squamous cell carcinoma, and female genital organs-related cancers like...
Single-cell nuclei transcriptome analysis of human adrenal glands indicated a sequential expression of ERα, GR, and RARα during development from progenitor to differentiated chromaffin cells. Further, in silico analysis revealed that patients with higher combined expression of GR, ERα, and RARα ...