The authors test their device in a group of paediatric patients at an audiology clinic and report a high level of agreement in audiologists’ classification of tympanograms produced using this device compared with a commercial device. Justin Chan Ali Najafi Shyamnath Gollakota ArticleOpen Access16...
The factors are important for selecting appropriate instruments to measure health status and health-related quality of life (HRQL) in a particular context. A study to evaluate treatment alternatives for patients with neurofibromatosis type 1 and congenital tibial dysplasia (NF1-CTD) provides a rich ...
Many studies on the origins, subtypes, and roles of brain macrophages have been conducted over the past decade. While our understanding of the origins, heterogeneity and functional states of these cells is still controversial in the field, data generated using single-cell technologies have led to ...
5]. Natural disease progression leads to cerebral hemorrhage or cerebral infarction, so early diagnosis and intervention before the establishment of a neurological deficit are essential for improved social adaptation of pediatric patients [6]. Nationwide epidemiological surveys are available in Japan...
The innovative medicine Artesun® is recommended by WHO for the treatment of severe malaria, which has saved more than 30 million patients in Africa. Till the end of 2020, Fosun Pharma had successfully launched three biosimilars—Han Li Kang®, Han Qu You® and Han Da Yuan®; the ...
While JAK2, CALR, and MPL mutations are considered driver events, mutations in other genes – particularly TET2, ASXL1, and DNMT3A – are found in over half of patients with MPN. Mutations affecting splicing regulators (SRSF2, SF3B1, U2AF1, ZRSR2) and other regulators of chromatin structure...
patients (excluding non-melanoma skin cancer) and 5377 non-cancer WTC-EHC participants who signed informed consent. We identified a total of 2999 cancer diagnoses in 2561 patients: 2534 solid tumors (84.5%) and 465 lymphoid and hematopoietic tissue cancers (15.5%) with forty-one different cancer...
ovarian cancer from June 2015 to August 2017. Patient wait times from referral to return of results were significantly shorter with the oncology clinic-based model as compared to the traditional model (403 vs. 191 days;p< 0.001). A subset of 148 patients (traditionaln= 99; oncology clinic-...
and patients typically die 20 years prematurely. Antipsychotic drugs have been the cornerstone and first-line treatment for schizophrenia over the last 60 years. However, they are ineffective or not tolerated in three-quarters of patients and, even where they are effective they have limited efficacy...
W. Kolch, et al., “Raf-1 protein kinase is required for growth of induced NIH/3T3 cells”, Letters to Nature, vol. 349, Jan. 31, 1991, pp. 426-428. M. Fridman, et al., “The Minimal Fragments of c-Raf-1 and NF1 That Can Suppress v-Ha-Ras-Induced Malignant Phenotype”,...