A third of patients with paraganglial tumors, pheochromocytoma, and paraganglioma, carry germline mutations in one of the susceptibility genes, RET, VHL, NF1, SDHAF2, SDHA, SDHB, SDHC, SDHD, TMEM127, and MAX. Despite increasing importance, data for long-term prognosis are scarce in ...
Neurofibromatosis 1 (NF1) mutation drives initiation of optic glioma through mediating dysregulation of neuronal activity and stimulating of optic nerve activity24. In the present study, we demonstrated that PILRΑ is abnormally expressed and associated with patients’ survival across different cancers. ...
Post-menopausal patients who control their emotions, particularly anger, to the extent of suppressing them, have a better prognosis than those patients who report emotional expression. Whereas for premenopausal women, control of anxious feelings are associated with a better prognosis. The findings are ...
TP53, PIK3CA mutant, and TERT amplification may serve as biomarkers for poor prognosis for CM patients.Introduction Breast cancer (BC) stands as the most prevalent malignancy among females worldwide, with cutaneous metastasis (CM) occurring in 5–30% of BC patients [1]. CM not only impacts ...
Cutaneous metastasis (CM) accounts for 5–30% of patients with breast cancer (BC) and presents unfavorable response to treatment and poor prognosis. A better understanding of the molecular alterations involved in metastasis is essential, which would help
MET-amplified solid tumors might be considered for targeted therapy, as MET amplification can be regarded as a risk factor affecting the prognosis of patients with tumors treated with immunotherapy. Keywords Melanoma, MET amplification, Immunotherapy †Xiaojun Cai, Jing Lin and...
Understanding the significance of PTPN11 mutations in adult AML can help identify novel therapeutic targets and develop more effective treatment strategies for adult AML patients. Therefore, in this study, we conducted a retrospective analysis of gene sequencing data from 232 adult AML (none APL) ...
(HMs).TP53missense mutations and 17p deletion are commonly seen in HM patients, with the absence or presence of mutant p53 associated with chemoresistance, relapse, and shorter patient survival. DeterminingTP53status could thus be beneficial for diagnosis and prognosis evaluation for HMs and for ...
Together, our findings suggest that combination therapy involving activation of several NHRs could be a promising pharmacological approach for differentiation treatment of NB patients.Background Neuroblastoma (NB), an embryonal tumor originating from neural crest derivatives of the sympathetic nervous system...
We also found recurrent activities of COSMIC Signatures 1, 3, 5, and 8 (Fig. 2b). In the ACGEJ genomes of our patients, 52.3% (257,673/493,106) of Signature 17 attributed SNVs were located at intergenic regions. We searched for potential cancer-driving regulatory elements in these ...