The impact of molecular pathology in these tumors is multifaceted and bears diagnostic, prognostic, and predictive implications although its use in the clinical practice is not completely assessed. Genomic profiling data claim that genetic alterations in poorly differentiated and anaplastic thyroid carcinoma...
Gastrointestinal stromal tumors with KIT exon 11 deletions are associated with poor prognosis. Gastroenterology 2006;130:1573–1581. Article CAS PubMed Google Scholar Cho S, Kitadai Y, Yoshida S et al. Deletion of the KIT gene is associated with liver metastasis and poor prognosis in patients ...
Children with brain tumours are frequent users of general paediatric services and an understanding of the spectrum of disease is indispensable when managing an affected family. This review aims to provide an overview of the aetiology, presentation, management, and prognosis of the major brain tumours...
Cutaneous melanoma (CM) is one of the most aggressive malignancies and its incidence is continuously increasing in the Caucasian population [1]. Melanoma is characterized by a molecular heterogeneity, considerably greater than that evidenced by the common histopathological features [2]. The melanoma pat...
and retroperitoneum. Histologically, these tumors are characterized by high cellularity and abundant mitotic activity. Surgical excision with negative margins is the preferred treatment. The images show a radiation-associated undifferentiated pleomorphic sarcoma, which has a particularly ominous prognosis.[7]...
VHMF VHMG VHML VHMS VHMW VHN VHNA VHND vHNF1 VHNI VHNK VHNW VHO VHOA ▼ Complete English Grammar Rules is now available in paperback and eBook formats. Make it yours today! Advertisement. Bad banner? Pleaselet us knowRemove Ads
when both techniques were combined this rose to 75% significantly improving the sensitivity than either test in isolation and rising again to 95% with repeated episodes [75]. The prognosis of childhood optic neuritis is generally better than in adults and studies have shown a 42%–55% incidence...
Until the recent approval of sotorasib, a KRAS G12C inhibitor, lack of targeted therapy for KRAS has resulted in poor prognosis of patients with tumors harboring KRAS mutations [1]. The KRAS protein is a GTPase that transmits intracellular signals upon binding to GTP [2], [3]. Under ...
6.9. Lung Cancer According to the TCGA data analysis, mutation frequency of FBXW7 was found to be 2.2% in 507 lung adenocarcinomas cases studied and 4.7% in lung squamous cell cancer cases studied which remarkably resulted in downregulation of FBXW7 leading to a poorer prognosis of lung ...
two urinary tumour studies pointed to miR-34-a function as an anti-metastatic microRNA by directly targeting CD44.10,17 Another predicted target gene identified was MYCN, the most relevant gene for NB prognosis, progression and treatment, which was reported to change in parallel with miR-34-a....