NF-KB通过与GSDMD启动子区域上游的两个近端位点结合而提高GSDMD转录，而抑制ERK1/2和NF-KB活性可以缓解...
黄连大黄药对调控 ROS/NF-KB/GSDMD信号通路 对2型糖尿病大鼠胰岛β细胞焦亡的影响 doi:10.13193/j.issn.1673-7717.2024.11.013Chinese Archives of Traditional Chinese Medicine陈源李振华岳仁宋杨茂艺
在LPC-vehicle小鼠中，Iba1+GSDMD+细胞显著上调，而在TGF-β1小鼠中则有所减少。同时，NLRP3凋亡小体及相关蛋白的上调也被TGF-β1给药所缓解，表明TGF-β1通过减少小胶质细胞的焦亡和凋亡，减轻LPC模型小鼠的神经炎症。
Mechanistically, CYLD, an intermediation for linking Qufeng epimedium decoction and RA, was responsible for Sirt1 deubiquitination to its protein stabilization, thereby deactivating the NF-kB /GSDMD signaling pathway. Conclusion Our findings indicate that Qufeng epimedium decoction suppresses FLSs pyroptosis...
(GSDMD) and F4/80 (macrophage marker), 3 and 7 days after tenotomy in mice with HO [25]. Since NF-κB is the central regulator of NLRP3 inflammasome activation, this inflammatory mechanism in macrophages might involve activating the transcription of pro-IL-1β and the NLRP3 gene, which ...
(2024). Phillyrin prevents sepsis-induced acute lung injury through inhibiting the NLRP3/caspase-1/GSDMD-dependent pyroptosis signaling pathway. Acta Biochimica et Biophysica Sinica, 57, 1–16. Li, J., Wen, H., & Gao, Z. (2020). In vitro inhibitory effects of phellodendrine on human ...
妇科调气解毒方通过下调炎性因子TNF-a,IL-6,IL-1β,IL-8,上调抑炎因子IL-10的表达,同时减少MPO的激活,从而抑制炎症.妇科调气解毒方通过降低基因NLRP3,GSDMD,Caspase-1,Caspase-1p20,TLR4,P-P65的m RNA的表达水平,以及下调蛋白NLRP3,GSDMD,Caspase-1,Caspase-1p20,TLR4,P-P65/P65的表达,来抑制由TLR4介导...
NF-KB通过与GSDMD启动子区域上游的两个近端位点结合而提高GSDMD转录,而抑制ERK1/2和NF-KB活性可以缓解单羧酸转运蛋白4(MCT4)诱导的细胞焦亡。免疫染色和WB结果显示,LPS处理的细胞中NF-KB大量入核,核内磷酸化的ERK1/2(p-ERK1/2)信号显著增加,而TGF-β1显著逆转了这一趋势。此外,ERK1/2和NF-KB通路激动剂...
NF-KB通过与GSDMD启动子区域上游的两个近端位点结合而提高GSDMD转录，而抑制ERK1/2和NF-KB活性可以缓解...
Specifically, SPD's binding to AhR plays a crucial role in modulating the inflammatory response and cellular pyroptosis by inhibiting both the AhR/NF-kB and NLRP3/caspase-1/GSDMD signaling pathways. Furthermore, the knockdown of AhR was found to negate the benefi...