在本研究中,我们首次通过生物信息学分析和临床标本检测发现了胶质瘤中RORA的异常低表达。通过基因集富集分析(GSEA)和体内外实验,我们发现RORA可能通过抑制TNF-α介导的NF-kB信号通路来抑制胶质瘤的增殖和肿瘤的发生。此外,由于microRNAs(...
这一集群在Cd137-/-TILs中有所减少,而在表达中央记忆T(Tcm)细胞和激活的T细胞特征基因的集群中富集(图1F-1I)。 对Cd137+/+和Cd137-/- CD8+ TIL差异表达基因进行的GSEA证实,Cd137+/+ TILs富集于慢性淋巴细胞性脉络膜炎病毒(LCM...
Biological pathway analysis was performed using Ingenuity Pathway Analysis (IPA) and Gene Set Enrichment Analysis (GSEA). Results : Expression of a core set of down-regulated visual cycle (RPE65, RLBP1, RDH5) and other RPE-related genes (BEST1, PMEL17, CRX) was significantly restored by BAY...
To explore the possible tumorgenic characteristic about TRIM52, gene set enrichment analysis (GSEA) was performed. Gene signature with the enrichment score positively associated with TRIM52 expression was selected from the MsigDB. Tissue specimens Forty ovarian serous adenocarcinomas patients with FIGO sta...
a GSEA plot showed miR-532-5p level was inversely correlated with angiogenesis gene signatures in the TCGA the stomach adenocarcinoma (STAD) data set. b and c The abilities of in vitro capillary tube formation (b) and migration (c) of HUVEC were significantly decreased after incubating with ...
1）TNF-α 可以选择英夫利昔单抗生物类似药（Infiximab Biosimilar）、阿达木单抗生物类似药（Adalimumab ...
Expression enrichment analysis was performed using either GSEA or ssGSEA. Immune cell infiltration was assessed using ESTIMATE.Results and conclusion: Pan-cancer analysis shown that, compared with peripheral non-tumor tissue, all five NF-kB member genes, NFKB1, NFKB2, REL, RELA and RELB, are...
基因集富集分析(GSEA)RNF7在非小细胞肺癌中可能的调控通路.Western blotting和荧光素酶检测RNF7对NF-κB信号通路的影响.ELISA和RT-qPCR观察趋化因子(C-X-C基序)配体1的表达情况.结果TCGA数据库分析显示RNF7在NSCLC中的表达水平显著上调,生存分析显示,肺癌患者中RNF7的表达水平越高,患者的预后越差(P<0.00...
通过基于TCGA和CGGA数据库的基因集富集分析(GSEA),我们发现RORA的低表达与肿瘤坏死因子介导的信号通路有关;通过体内和体外实验,我们发现RORA可能通过抑制TNF-a介导的NF-kB信号通路来抑制胶质瘤的增殖和肿瘤的发生。此外,由于microRNAs(Mi...
Gene Set Enrichment Analysis (GSEA) and Gene Oncology (GO) enrichment analysis were performed using RNAseq results. RT-PCR and immunoblotting were used to validate findings from RNAseq and enrichment analysis.Results: Compared with normal prostate, transcript levels of PRDX4 are found to be up...