此外，WB结果证明了TGF-β1显著减弱了LPS刺激下培养的小胶质细胞中GSDMD、NLRP3、Caspase-1-p20和IL-1β蛋白水平的升高。实验表明，TGF-β1通过ERK1/2和NF-KB途径直接抑制小胶质细胞的焦亡过程，减少促炎细胞因子和神经炎症的释放。NF-KB通过与GSDMD启动子区域上游的两个近端位点结合而提高GSDMD转录，...
此外，WB结果证明了TGF-β1显著减弱了LPS刺激的培养小胶质细胞中GSDMD，NLRP3，Caspase-1-p20和IL-1β...
Emodin Suppresses NLRP3/GSDMD-induced Inflammation via the TLR4/MyD88/NF-κB Signaling Pathway in Atherosclerosisdoi:10.1007/s10557-024-07659-wInflammatory responses induced by NLRP3 inflammasome contribute to the progression of atherosclerosis. This study seeks to investigate the effect of emodin on ...
Remarkably, NLRP5 has been involved in POI in human and mice.15 Moreover, a very recent study based on mouse models highlights the important role of inactivated NF–KB in POI.16 ELAVL2: In a Polish family, two sisters developed POI with SA at 20 and 24 years. Show abstract Both parti...
4A–E). The findings of western blot analysis showed that OE-EXO up-regulated the pyroptosis-associated NLRP3/caspase-1/GSDMD axis (Fig. 5A). In comparison to the control, cleaved caspase-8/3 and Bax were significantly overexpressed in the OE-EXO group, while anti-apoptotic protein Bcl-2...
(COL-Ⅰ)、COL-Ⅲ和肝细胞上清液中丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、白细胞介素1β(IL-1β)、IL-18的含量,以及2种细胞中TLR4、核因子κB抑制蛋白α(IκBα)、NF-κBp65、NLRP3、GasderminD(GSDMD)、凋亡相关微粒蛋白(ASC)mRNA和TLR4、磷酸化IκBα(p-IκBα)、NF-κBp65、NLRP3、GSDMD、ASC...
总之,我们开发了一个基于焦亡枢纽基因(如CASP1、IL-1β、GSDMD和NLRP3)的IVDD预测模型,发现IVDD的发病机制主要与细胞凋亡和焦亡等信号通路的异常表达有关。我们最终证实,在治疗IVDD中,DHJSD通过SDF1/CXCR4-NFkB-NLRP3轴抑制椎间盘促炎因子的产生和NPCs焦亡。尽管DHJSD抑制NPCs焦下垂的具体机制已经得到证实,但尚不...
Download: Download high-res image (569KB) Download: Download full-size image Fig. 7. Schematic summary of the signal pathways involved in this study. The CaMKII/NF-κB p65/NLRP3/GSDMD signaling axis was activated after ICH then leaded to inflammation and pyroptosis in the brain. The activatio...
目的基于磷脂酰肌醇3-激酶(PI3K)-蛋白激酶B(PKB/Akt)/核因子κB(NF-κB)信号通路,探讨大黄糖络丸(RSP)防治Zucker糖尿病肥胖(ZDF)大鼠大血管炎症反应的作用机制。 方法15只雄性ZDF(fa/+)大鼠作为对照组;高脂饲料诱导成模的75只雄...
DNA病毒,是否可以激活NLRP3和AIM2炎症小体进而诱导IL-1β的分泌?这 些问题至今依然不清楚。 目前,利用基因敲除小鼠模型是回答炎症反应机制关键科学问题最可靠有效 -/--/--/--/- PRVWTAim2Nlrp3AscCaspase-1 的手段。因此,本研究将利用感染、、、 -/--/- Gsdmd和Gsdme等基因敲除小鼠深入探究这些科学问题。