(C) KEGG pathway analysis (D–K) The targets of NF-κB pathway signaling (NKFB1, Il-6, TNF, Il-1b, and IKBKB) and The targets of AhR–FAS signaling (AhR, FAS, and SREBP-1c). (For each group, n = 10, * p < 0.05; ** p < 0.01; *** p < 0.001). Metascape and KEGG...
In our study we show a counter-regulatory link between AR and NF-κB both in human cells and in mouse models of prostate cancer, implying that inhibition of AR signaling results in induction of NF-κB-dependent inflammatory pathways, which may even foster the survival of metastasizing cells. ...
Figure 5. Effects of intrauterine growth restriction (IUGR) on colonic Nrf2/Keap1 signaling pathway in growing-finishing pigs (n = 6). * p < 0.05. C25, C50, and C100 represent the samples obtained from the colonic mucosa of pigs when the normal birth weight (NBW) pigs reached 25, 50,...
Inflammatory bowel disease (IBD) incidence has increased in the last decades due to changes in dietary habits. IBDs are characterized by intestinal epithelial barrier disruption, increased inflammatory mediator production and excessive tissue injury. Sin