方法:本研究通过GEO数据库下载数据集GSE142153进行差异基因(DEGs)筛选,GO/KEGG显示DEGs参与的分子生物学过程.通过在线网站STRING构建PPI蛋白互作网络,在Cytoscape中通过插件"cyto Hubba"筛选中心基因.通过构建WGCNA识别关键模块和中心基因,联合PPI与WGCNA识别真正的中枢基因.应用验证集GSE65561,GSE85011分析受试者工作特征...
The gene–microRNA interaction diagram (A) shows the direct target genes, PTEN and TIMP2, of hsa-miR-181b-5p; the radar plot (values: −log10 FDR) represents the significant (B) KEGG pathways and (C) reactome pathways regulated by miR-181b-5p; the bar graphs show the comparative ...
KEGG PATHWAY: NF-Kappa B Signaling Pathway—Reference Pathway’. Available online: https://www.kegg.jp/pathway/map=map04064&keyword=nfkb (accessed on 8 January 2024). Savinova, O.V.; Hoffmann, A.; Ghosh, G. The Nfkb1 and Nfkb2 Proteins p105 and p100 Function as the Core of High-...
(KEGG) public pathway database, there were six pathways difference between control and ACR-treated groups—namely, organismal systems, metabolism, human disease, genetic information processing, environmental information processing, and cellular processes (Figure 3). The numbers 27, 14, 7, and 6 of ...
Among these, KEGG pathway analyses have indicated that Rg1-mediated anti-ALD activity is derived from its inhibitory effects on TLR/NF-κB signaling. Studies have confirmed that alcohol-induced hepatocyte injury in ICR mice is healed by Rg1 treatment. Levels of biomarkers that represent liver ...
To test the potential regulatory mechanisms of Morusin on alleviating LPS-induced inflammation in RECs, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis were conducted for the overlapping DEGs to define their biological functions. The results showed that a to...
Furthermore, KEGG pathway analysis and enrichment of GO terms ascertained a considerable enrichment of genes involved in PPAR signaling pathway, insulin signaling pathway, and NF-κB signaling pathway (Figure 3c). The top 10 biological processes (BP), cellular components (CC), and molecular ...
Objectives: Calcific aortic valve disease (CAVD) is most common in the aging population and is without effective medical treatments. Brain and muscle ARNT-like 1 (BMAL1) is related to calcification. It has unique tissue-specific characteristics and plays
Inflammatory bowel disease (IBD) incidence has increased in the last decades due to changes in dietary habits. IBDs are characterized by intestinal epithelial barrier disruption, increased inflammatory mediator production and excessive tissue injury. Sin