The expression of pro-inflammatory genes like IL-1B, IL-6, and CXCL8 was downregulated in A431 cells upon CAP treatment. Notably, CAP enhanced the expression of antioxidant response genes HMOX1 and GPX1 in non-malignant cells. The differential response between HaCaT and A431 cells underscores...
NF-κB是对有害细胞刺激的第一反应者。已知的NF-κB通路激活的炎症与免疫相关的因子有很多，包括促炎细胞因子（TNF-α、IL-1β、IL-6、IL-12、趋化因子(CXCL8（IL-8）、CCL2（MCP-1）、CCL5（RANTES）)、免疫受体（CD80/CD86）、抗原提呈分子（MHC I/II类分子）等。细胞存活与凋亡调控基因如：抗凋亡蛋...