NF-κB is involved in the CCL2 expression induced by BRD4 Fig. 6: NF-κB is required for BRD4-induced CCL2. Full size image Macrophages activated by CCL2 stimulate tumor progression Fig. 7: BRD4-upregulated CCL2 activates TAMs. Full size image ...
neddylation pathway promotes CCL2 transactivation and TAMs infiltration in lung cancer to provide a tumor-promoting microenvironment, which validates neddylation pathway as a promising target for anti-TAMs therapeutic strategies.
NFκB: Nuclear factor kappa B PCR: Polymerase chain reaction RT: Reverse transcription TNF-α: Tumor necrosis factor-α VEGF: Vascular endothelial growth factor References Feuerstein GZ, Wang X, Barone FC: The role of cytokines in the neuropathology of stroke and neurotrauma. Neuroimmunomod...
Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38 J. Biol. Chem., 276 (22) (2001), pp. 18934-18940 View PDFView articleView in ScopusGoogle Scholar [54]...
(Shen et al.2016). The researchers also suggested that CCL2 overexpression might promote the formation of CAFs. It's interesting to note that CAFs promote cancer spread by producing CCL2. In cocultured cancer-associated fibroblasts, the amplification of nuclear factor kappa and STAT3 significantly...
Communication between NF-kappa B and Sp1 controls histone acetylation within the proximal promoter of the monocyte chemoattractant protein 1 gene J Immunol, 170 (2003), pp. 4139-4147 CrossrefView in ScopusGoogle Scholar 25 WS Sheng, S Hu, HT Ni, TN Rowen, JR Lokensgard, PK Peterson TNF-...
Cysteine-rich 61 (Cyr61 or CCN1), a secreted protein from the CCN family, is an important proinflammatory cytokine. Migration and infiltration of mononuclear cells to inflammatory sites play a critical role in the pathogenesis of rheumatoid arthritis (RA
was more abundant in progesterone receptor (PR)-negative tumors than in PR-positive tumors and was abundant in high-grade tumors. High expression levels of CCL2, CXCL8, and CCL4 were correlated with strong infiltration of inflammatory cells, such as B cells, T cells, and CD68+macrophages [...
Viral induction of inflammatory cytokines in human epithelial cells follows a p38 mitogen-activated protein kinase-dependent but NF-kappa B-independent pathway J. Immunol., 171 (2003), pp. 3768-3774 CrossrefView in ScopusGoogle Scholar Meyer et al., 2011 U. Meyer, J. Feldon, O. Dammann Sch...
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