NF-kappa BMast Cells (MCs) are critical for allergic reactions but also play important roles in inflammation, following stimulation by non-allergic triggers such as cytokines. Upon stimulation, MCs secrete numerous newly synthesized mediators, but the mechanism of the release of chemokines, which ...
NF-κB is involved in the CCL2 expression induced by BRD4 Fig. 6: NF-κB is required for BRD4-induced CCL2. Full size image Macrophages activated by CCL2 stimulate tumor progression Fig. 7: BRD4-upregulated CCL2 activates TAMs. Full size image ...
correlated with high CCL2 expression in lung adenocarcinoma, conferring a worse overall patient survival. Together, neddylation pathway promotes CCL2 transactivation and TAMs infiltration in lung cancer to provide a tumor-promoting microenvironment, which validates neddylation pathway as a promising target f...
NFκB: Nuclear factor kappa B PCR: Polymerase chain reaction RT: Reverse transcription TNF-α: Tumor necrosis factor-α VEGF: Vascular endothelial growth factor References Feuerstein GZ, Wang X, Barone FC: The role of cytokines in the neuropathology of stroke and neurotrauma. Neuroimmunomodu...
TNF alpha receptors are constitutively overexpressed in tumor cells, correlating to sustain elevated NF kappa B and monocyte chemotactic protein-1 (MCP-1/CCL2) expression. The elevation of CCL2 evokes aggressive forms of malignant tumors marked by tumor associated macrophage (TAM) recruitment, cell ...
Mechanistically, PIM1 deficiency facilitates the reprogramming of TAMs by targeting nuclear factor kappa beta (NF-魏B) signaling and inhibits CCL2 transactivation by NSCLC cells. The decreased secretion of CCL2 impedes TAM accumulation and their polarization toward a pro-tumoral phenotype. Furthermore,...
Cysteine-rich 61 (Cyr61 or CCN1), a secreted protein from the CCN family, is an important proinflammatory cytokine. Migration and infiltration of mononuclear cells to inflammatory sites play a critical role in the pathogenesis of rheumatoid arthritis (RA
Nuclear factor of κB (NF-κB) is a transcription factor that regulates the transcription of many genes involved in inflammatory and immune responses. The promoter region of the human and mouseCCL2/Ccl2gene contains two NF-κB binding sites in the distal region, and they are particularly import...
Hyperbaric Oxygen Alleviates the Inflammatory Response Induced by LPS Through Inhibition of NF-κB/MAPKs-CCL2/ CXCL1 Signaling Pathway in Cultured Astrocyteshyperbaric oxygenastrocytesCCL2CXCL1LPSThe purpose of this study was to investigate the inhibition neuroinflammation mechanisms of hyperbaric oxygen ...
Furthermore, blocking 1L-6 or CCL2 or the transcription factor NF-kappa B induced the inhibition of tube formation in HUVECs co-cultured with PA28 gamma-overexpression OSCC cell supernatants. Moreover, we revealed that p-STAT3 and p-AKT, which are downstream of the IL-6 and CCL2 ...