Full size image Next, we examined the possible mechanism of p75NTR-related release of endothelial MPs. Previous studies have identified the role of Rho kinases (ROCK)26,27and NF-κB pathways28in the biogenesis of MPs and their release in different cellular contexts. Following p75NTRoverexpression,...
Disruption of tissue function activates cellular stress which triggers a number of mechanisms that protect the tissue from further damage. These mechanisms involve a number of homeostatic modules, which are regulated at the level of gene expression by the transactivator NF-κB. This transcription facto...
The invention relates to a family of fungal compounds which are inhibitors of NF-κB inducing kinase and are thus useful in the treatment of NF-κB-related diseasesor disorderssuch asinflammatory or autoimmune diseasesor disorders.FERNNDEZ MEDARDE, ANTONIO...
MAP3K-related kinase involved in NF-κB induction by TNF Several members of the tumour-necrosis/nerve-growth factor (TNF/NGF) receptor family activate the transcription factor NF-B through a common adaptor protei... NL Malinin,MP Boldin,AV Kovalenko,... - 《Nature》 被引量: 2010发表: ...
In this study, we asked if the non-oncogenic Tax-2 of the related HTLV-2 is still able to induce Fascin by using luciferase assays, immunoblot, and qPCR. We found that Tax-2 only slightly induces Fascin expression compared to Tax-1; however, both Tax-1 and Tax-2 comparably activated ...
Unlike TNFα, TRAIL is a weak inducer of inflammation (Song et al., 2000), an important property which is probably related to its poor NF-κB activating ability (Ashkenazi et al., 1999). Administration of recombinant TRAIL suppresses the growth of tumor xenografts with no apparent systemic ...
macrophages, endothelial cells and extracellular matrix (ECM) including collagen. Investigating the stromal compartment can, however, be complicated as the stroma is not static. Cellular and ECM compositions evolve over time, adapting to changes related to the surrounding epithelial cells (Kass et al,...
Compositions and Methods of Use of the inhibitor of the transcription activator NF-kappaB, whose applications include identifying prophylactics or therapeutics for the treatment of diseases resulting from a change in the expression of genes, including genes that encode cytokines or related molecules.收藏...
Thus the pathological stress-triggered hyperactivation of NF-κB signaling may contribute to bone ageing-related diseases such as osteoporosis, spontaneous fracture (Saad, 2020), and osteoarthritis (Lepetsos, Papavassiliou et al., 2019). Rashmi Mishra et al. (Mishra, Sehring et al., 2020) rece...
NF-κB is constitutively activated in psoriatic epidermis. However, how activated NF-κB promotes keratinocyte hyperproliferation in psoriasis is largely unknown. Here we report that the NF-κB activation triggered by inflammatory cytokines induces the t