Nuclear staining for NFKB was localized predominantly to perivascular microglia/macrophages in the BG and DWM and correlated with ADC severity. Correlations were further found with HLA-DR, iNOS, TNF-伪, and gp41 expression in these regions. The number of TUNEL-positive cells, particularly in ...
有研究表明NF-KB在肿瘤血管生成过程中可能具有核心的调节作用,同时诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)的活性亦与肿瘤的血管生成具有密切关系。众多学者的研究结果显示,NF-KB除了调节iNOS继之调节VEGF外,其他血管生成因子如TGF-B、TNF-α、IL-12ct、IL-8均含有NF-KB的特异性结合位点,其表达...
IKKbeta is essential for protecting T cells from TNFalpha-induced apoptosis. Im- munity 2001; 14:217-230. 58 Jimi E, Strickland I, Voll RE, Long M, Ghosh S. Differential role of the transcription factor NF-kappaB in selection and survival of CD4+ and CD8+ thymocytes. Immunity 2008; ...
活化的NF-KB转位到核内与其相关的DNA基 序结合以诱导靶基因的转录。这种方式的NF-KB活化途径被称为经典的NF-KB活化途径。NF-KB通过该途径调节的目的基因有炎症介质、细胞因子(如TNF-aIL-1等)、黏附分子、急性期蛋白及可诱导的效应期酶等。其他的不被人所熟知的途径也能从IKBs中活化部分的NF-KB。这些途径包括...
NF-kB and TNF-alpha: a positive autocrine loop in human lung mast cells? J Immunol 2002; 169: 5287–5293. Article Google Scholar Bauvois B . Transmembrane proteases in cell growth and invasion: new contributors to angiogenesis? Oncogene 2004; 23: 317–329. Article CAS Google Scholar ...
NF-B能够高效诱导炎症细胞因子(TNF-、IL-1、IL-6等)、趋化因子、黏附分子(ICAM-1、VCAM-1)、炎性酶(iNOS、COX-2)等的基因表达,对炎症反应级联放大,在多种炎症性疾病的炎症部位高度活化。因此NF-B是许多炎症细胞因子的转录因子,在炎症反应中起着要紧作用。4. 检测方法4.1蛋白印迹(Western blot)能够从两个...
有研究表明NF-KB在肿瘤血管生成过程中可能具有核心的调节作用,同时诱导型一氧化氮合酶(induciblenitricoxidesynthase,iNOS)的活性亦与肿瘤的血管生成具有密切关系。众多学者的研究结果显示,NF-KB除了调节iNOS继之调节VEGF外,其他血管生成因子如TGF-B、TNF-α、IL-12ct、IL-8均含有NF-KB的特异性结合位点,其表达受NF...
有研究表明NF-KB在肿瘤血管生成过程中可能具有核心的调节作用,同时诱导型一氧化氮合酶(inducible nitric oxide synthase,iNOS)的活性亦与肿瘤的血管生成具有密切关系。众多学 8、者的研究结果显示,NF-KB除了调节iNOS继之调节VEGF外,其他血管生成因子如TGF-B、TNF-、IL-12ct、IL-8均含有NF-KB的特异性结合位点,其...
S9502Madecassic acidMadecassic acid (Brahmic acid), a natural triterpene first isolated from C. asiatica, has diverse anti-inflammatory and anti-diabetic effects, blockingNF-κBactivation in macrophages and causing byiNOS,COX-2,TNF-alpha,IL-1betaandIL-6inhibition. ...
Laboratory Investigation (2011) 91, 413–425 & 2011 USCAP, Inc All rights reserved 0023-6837/11 $32.00 TNFR2 interposes the proliferative and NF-kB-mediated inflammatory response by podocytes to TNF-a Leslie A Bruggeman1, Paul E Drawz1, Nicole Kahoud3, Ke Lin2, Laura Barisoni2 and ...