英文别名: TBK1 (TANK-Binding Kinase 1, NFkB Activating Kinase, NAK, T2K) (HRP)中文名: 中文别名: CBNumber: CB04944647 分子式: 分子量: 0 MOL File: Mol file 化学性质 安全信息 用途 供应商 1 TBK1 (TANK-Binding Kinase 1, NFkB Activating Kinase, NAK, T2K) (HRP)化学性质...
IKK / NF-kB信号通路是代谢,炎症和胰岛素作用之间联系的关键。无论是由细胞内还是细胞外线索引起的导致胰岛素抵抗或胰腺β细胞功能异常的大多数代谢应激信号都集中在NF-kB激活激酶IKKb和其他主要的炎性激酶JNK-促分裂原活化蛋白激酶(MAPK)上。 2. NF-kB与氧化代谢有关: NF-kB通过控制糖酵解和呼吸之间的平衡来控...
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1.利用KO细胞系证明TRAF3在RNA和DNA通路中的作用 有相关研究表明肿瘤坏死因子(TNF)受体相关因子3 (TRAF3)在RNA途径中介导IFN的激活中发挥重要作用。从机制上讲，TRAF3与RNA通路中的适配器IPS-1有关，驱动信号激活到TBK1-IRF3信号轴。Kislay等从其他研究者那里获取到关键敲除细胞系（Traf2−/−、Sting−/−...
别名:TRAF-associated NF-κB kinase; TANK protein; TANK-binding kinase 1; T2K; NF-kappa-B-activating kinase; Serine/threonine-protein kinase TBK1; I TRAF; ITRAF; TRAF family member associated NF KAPPA B activator; TRAF family member associated NFKB activator; TRAF interacting protein; TR...
Scroll over each target protein for more information ATM (P-Ser1981) eIF-2a (P-Ser52) HDAC2 (P-Ser394) HDAC4 (P-Ser632) IKB-alpha (P-Ser32) MSK1 (P-Ser376) NF-kB (P-Ser536) STAT1 (P-Ser727) TAK1 (P-Ser412) TBK1 (P-Ser172) ZAP70 (P-Tyr292)...
(c-IAP2), FADD, IRAK1, IRAK2, IRF1, MYD88, RIPK1, TBK1, TICAM1 (TRIF), TNFAIP3, TRADD, TRAF2, TRAF3, TRAF6. Cytoplasmic Sequestering/Releasing of NFκB: BCL3, CHUK (IKKa), IKBKB, IKBKG, NFKBIA, NFKBIE. Transcription Factors: NFKB1, NFKB2, REL, RELA, RELB. NFκB Responsive...
In addition, NIK is negatively regulated by two homologous kinases, IKKα and TBK1 [39, 40]. These kinases phosphorylate NIK and promote degradation of NIK even when it is released from TRAF3. NF-κB in inflammation Inflammation is a body’s protective response to infections and tissue ...
Pomerantz JL, Baltimore D: NF-KB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase. Embo J 18: 6694–6704, 1999Pomerantz, J.L., and Baltimore, D. (1999). NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel...
此外,作者通过过表达p65/RelA来激活NF-κB信号,发现通过Etop、TG或ST的凋亡诱导在报告的检测中极大地抑制了p65诱导的NF-κB-luc活性(图3B)和p65诱导的细胞因子的产生(图3C)。此外,与以前的研究一致,TBK1或IRF3诱导的ISRE-luc活性也被凋亡诱导所抑制(图3B)。这些数据表明,细胞凋亡通过caspase-3抑制NF-κB信号。