Methods The mRNA expression of macrophage polarization-related factors in the microenvironment of periodontal inflammation was detected using real-time quantitative PCR (RT-qPCR). The experimental periodontitis model was constructed in wild-type (WT) and T2DM (db/db) mice, which were administered BBR...
Knockdown of HOXD9 led to macrophage M2 polarization, and overexpression of APOC1 polarized macrophage M1. In addition, enhanced p65 phosphorylation verified that HOXD9/APOC1 induced macrophage M1-type polarization by activating the NF-κB signaling pathway. Knocking down APOC1 enhanced the inhibitory...
Notably, neutralizing antibodies against IL-33 or ST2L block NF-κB activity, suppress M2 macrophage polarization, and synergistically inhibit tumor growth when combined with cisplatin treatment in vitro/vivo. Clinically, Rab37+/ST2L+/CD206+ tumor-infiltrating M2 macrophages correlate with advanced-...
whi ay provide a theory basis for research of macrophage polarization . [Key words ] Macrophage; Polarization; Regulation , 和CD80 识别 促炎介质肿瘤坏死因子( tumor 最早期对巨噬细胞极化的描述为 当机体受到 T , necrosis factor ,TNF) - 、 ( IL)-12、IL-6 , 外界刺激进行 细胞应答时 招募的巨...
MRC1 to understand macrophage polarization in renal tissues. The expression of inflammatory mediators TNF-α and IL-1β in kidney tissues were detected by immunohistochemical staining and RT-PCR, and the expression of TLR4/NF-kB pathway related protein in kidney tissues was analyzed by Western...
目的探究天麻素联合塞来昔布通过Toll样受体4(TLR4)/核因子-κB(NF-κB)信号通路对膝骨关节炎大鼠软骨损伤的保护作用。 方法采用改良Hulth法制备膝骨关节炎大鼠模型,按照随机数字法随机分为模型组、天麻素组、塞来昔布组和联合组,每组10只,另选10只健康大鼠作为对照组。天麻素组腹腔注射50 mg/kg天麻素注射液;塞...
Overall, the above results signified that the high sugar-treated podocyte exosome APOC1 induced macrophage M1-type polarization. HOXD9 modulated exosomal APOC1 derived from HG-stimulated HPC To identify the transcription factors that regulate APOC1, this study predicted the transcription factors of APO...
Key words: atherosclerosis; macrophage polarization; levosimendan; TLR4/NF-κB signaling pathway 心血管疾病是一类高发病率和高死亡率的疾 病,据统计,每年约有 2 000 万人死于心血管疾病[1]. 动脉粥样硬化(atherosclerosis,AS)作为慢性血管炎 性疾病之一 ,是脑卒中和心律不齐等心脑血管疾病 的主要原因.AS ...
HMOX-1, a M2 macrophage enzyme with anti-oxidant activities, plays a functional role in restoring and maintaining cell anti-oxidant capacity, which in turn enhances the M1 to M2 macrophage polarization via the suppression of inflammation and mediating the production of IL-10 (an M2 stimulus) (...
As NF-κB is a key regulator of macrophage polarization, we developed an in vivo TAM-targeting delivery system that combines mannose-modified bubble liposomes/NF-κB decoy complexes (Man-PEG bubble lipoplexes) and ultrasound (US) exposure. We investigated the effects of NF-κB decoy transfection...