NF-kappa B and TNF-alpha: a positive autocrine loop in human lung mast cells? J. Immunol. 169, 5287-5293.Coward WR,Okayama Y,Sagara H,et al.NF-kappa B and TNF-alpha: a positive autocrine loop in human lung mast cells[]..2002...
Signaling pathway via TNF-alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis Watanabe. Signaling pathway via TNF- alpha/NF-kappaB in intestinal epithelial cells may be directly involved in colitis-associated carcinogenesis. Am J ... M Onizawa,...
TNF-alphaProstate cancer (PCa) frequently metastasizes to the bone leading to devastating complications such as severe pain and fracture. However, the mechanisms by which PCa cells cause bone loss remain less understood. We investigated the role and mechanisms by which PCa cells induce ...
2) OPG/RANKL 护骨素/核因子κB受体活化因子配基 3) RANKL 核因子-κB受体活化因子配体 1. Objective To study the effects of tumor necrosis factor-alpha(TNF-α)on the gene expression of receptor activator of nuclear factor-κB ligand(RANKL) and osteoprotegerin(OPG) in human periodontal ligament...
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CAPE prevented the translocation of the p65 subunit of NF-kappa B to the nucleus and had no significant effect on TNF-induced I kappa B alpha degradation, but did delay I kappa B alpha resynthesis. The effect of CAPE on inhibition of NF-kappa B binding to the DNA was specific, in as ...
Induction of apoptosis and NF-$\\kappa$B by quercetin in growing murine L1210 lymphocytic leukaemic cells potentiated by TNF-$\\alpha$ Polyphenol quercetin induced apoptosis in proliferating murine L1210 lymphocytic cells. DNA damage, as well as apoptosis and withdrawal from the cell cycle... A...
Silymarin blocked TNF-induced activation of NF-kappa B in a dose- and time-dependent manner. This effect was mediated through inhibition of phosphorylation and degradation of Iota kappa B alpha, an inhibitor of NF-kappa B. Silymarin blocked the translocation of p65 to the nucleus without ...
Activation of NF-κB was stimulated by 20 ng/ml TNFα (Sigma). NF-κB Modulation Plasmids Modulation of NF-κB signaling utilized transient plasmid overexpression by attractene transfection. Plasmids: IKK (IKK-2 S177E, S191E) and IKBα (pBabe-Puro-IKBalpha- mut(superrepressor)) plasmids (...
TAB2 is an adapter protein that facilitates TNFalpha and IL-1beta-mediated NF-kappaB activation. In this work, using yeast two-hybrid system TAB2 was identified to interact with NUMBL. The interaction was further confirmed in vitro and in vivo. PTB domain of NUMBL and C-terminal region are...