The present review envisages the role of nanovaccines to combat the global challenges of antimicrobial resistance. Nanovaccines are a novel formulation comprised of nanomaterials coupled with an immunogenic component to elicit the immune response and pro
Due to the wide-ranging impact of the COVID-19 pandemic, there has been a renewed interest inproactive vaccinology, in which research efforts are concentrated on designing vaccines that can induce immunity that would cross-protect against future zoonosis. A pan-coronavirus vaccine could therefore re...
The mRNA vaccine platform has offered the greatest potential in fighting the COVID-19 pandemic owing to rapid development, effectiveness, and scalability to meet the global demand. There are many other mRNA vaccines currently being developed against different emerging viral diseases. As with the ...
Breast cancer, the world’s most commonly diagnosed cancer, is a heterogeneous disease that demands appropriate diagnosis for better patient management. Thus, the understanding of the molecular mechanisms of tumor heterogeneity, as well as the characteri
Nowadays, the landscape of cancer treatments has broadened thanks to the clinical application of immunotherapeutics. After decades of failures, cancer immunotherapy represents an exciting alternative for those patients suffering from a wide variety of ca
This review will discuss the potential use of PLGA-NPs, liposomes, and EVs as carriers of peptides, adjuvants, mRNA, and DNA for the development of next-generation vaccines against endemic and emerging viruses in light of the recent COVID-19 pandemic. Keywords: advanced vaccines; PLGA; ...
The scarcity of an effective method for manipulating viral genomes has impeded research progress in PEDV biology and vaccinology. Here, we report the development of reverse genetics systems using two novel infectious full-length cDNA clones of a Korean highly pathogenic-G2b strain, KNU-141112, and...
The development of next-generation vaccines that could confer broad protection against both the SARS-CoV-2 Wuhan strain and VOCs is urgently needed. A bivalent mRNA vaccine encoding the Spike proteins of both the SARS-CoV-2 Wuhan strain and the Omicron variant has been constructed and approved ...
viruses Review Universally Immune: How Infection Permissive Next Generation Influenza Vaccines May Affect Population Immunity and Viral Spread Maireid B. Bull 1, Carolyn A. Cohen 1, Nancy H.L. Leung 2 and Sophie A. Valkenburg 1,* 1 HKU-Pasteur Research Pole, School of Public Health, The ...