HER2 positiveTargeted therapiesDrugs in developmentAdvanced breast cancerSince the identification of the HER2 receptor amplification as an adverse prognostic factor that defined a special subtype of metastatic breast cancer, there has been a substantial improvement in survival of patients affected with this...
“There have been many advances in the development of drugs for HER2-positive breast cancer since the introduction of Herceptin (trastuzumab) in 1998. The approval of Enhertu represents the newest treatment option for patients who have progressed on available HER2-directed therapi...
Over the past 18 months, the FDA has approved 4 new regimens for HER2-positive metastatic disease.In an interview with Pharmacy Times, Kelly Gaertner, PharmD, an oncology clinical pharmacy specialist with Allegheny Health Network, said that a slew of new treat...
Next, O’Shaughnessy reviewed recent developments in the treatment of HER2-positive breast cancer. Tucatinib very selectively inhibits HER2, she said, allowing it to get great brain penetration. The randomized HER2CLIMB trial saw not only improvements in progression-free survival (PFS), but also...
7 Tripathy said it was interesting “the outcome was so much better in the T-DM1—based treatment group.” The results led the FDA to expand indications for T-DM1 in May 2019 to include patients with early-stage HER2-positive breast cancer and residual invasive disease after neoadjuvant ...
breast tumors including luminal subtypes (hormone receptor positive), HER2 subtype, and a basal-like subtype. In parallel have been the development and implementation of specific targeted therapies that have not only allowed for more treatment options to be available but have altered the natural ...
HER2‐positive breast cancerT‐DM1trastuzumabtucatinibBackground Brain metastases (BrM) incidence is 25% to 50% in women with advanced human epidermal growth factor receptor 2 (HER2)﹑ositive breast cancer. Radiation and surgery are currently the main local treatment approaches for central nervous ...
While the introduction of HER2... A Awada,I Bozovic-Spasojevic,L Chow - 《Cancer Treatment Reviews》 被引量: 101发表: 2012年 Pertuzumab: new hope for patients with HER2-positive breast cancer Human epidermal growth factor receptor 2 (HER2) overexpression is detected in approximately 15% to ...
Discovery Of Gene That Causes HER2 Breast Cancer To Spread Raises Hope For New TreatmentScientists in Scotland have identified a gene that plays a key role in the spread of HER2 positive to other parts of the body, raising hopes of a new treatment for this common form of breast cancer....
Resistance to therapy is a major problem in the cancer field. Even when a treatment initially works, the tumors often find ways around the therapy. Using human cell lines of the HER2-positive breast cancer subtype, researchers from the UNC School of Medicine and UNC Lineberger Comprehensive Canc...