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[1] Shi Q, Xuhong J, Luo T, et al. PIK3CA mutations are associated with pathologic complete response rate to neoadjuvant pyrotinib and trastuzumab plus chemotherapy for HER2-positive breast cancer. Br J Cancer. 2023;128(1):121-129. ...
The overexpression of human epidermal growth factor receptor-2 (HER2) results in a biologically and clinically aggressive breast cancer (BC) subtype. Since the introduction of anti-HER2 targeted agents, survival rates of patients with HER2-positive metastatic BC have dramatically improved. Currently, ...
The long-sought discovery of HER2 as an actionable and highly sensitive therapeutic target was a major breakthrough for the treatment of highly aggressive HER2-positive breast cancer, leading to approval of the first HER2-targeted drug — the monoclonal antibody trastuzumab — almost 25 years ago....
9、Xu B, Yan M, Ma F, et al. Pyrotinib plus capecitabine versus lapa-tinib plus capecitabine for the treatment of HER2-positive metastatic breast cancer (PHOEBE): a multicentre, operrlabel, randomised, controlled, phase 3 trial[J]. Lancet Oncol, 2021, 22(3):351-360. ...
[2] VAN RAMSHORST MS, VAN DER VOORT A, VAN WERKHOVEN ED, et al. Neoadjuvant che-motherapy with or without anthracyclines in the presence of dual HER2 blockade for HER2-positive breast cancer (TRAIN-2): a multicentre, op...