New insights into thyroid hormone action. Best Pract Res Clin Endocrinol Metab 2007; 21:193-208.etting A, ] en PM (2007) New insights into thyroid hormone action. Best Pract Res Clin Endocrinol Metab. 21: 193-208.Oetting, A., and P. M. Yen. New insights into thyroid hormone action....
It has already been established that the thyroid hormones T3 and T4 modulate cancer hallmarks including cell proliferation, cell apoptosis, new angiogenesis, and invasiveness of cancer17. Thyroid hormones perform their action through thyroid hormone receptors (THRs) that act as ligand-dependent ...
(iodothyronine deiodinase, type I), an essential gene for thyroid hormone action given that it codes for an oxidoreductase involved in thyroid hormone activation by converting the prohormone T4 into bioactive 3,5,3'-triiodothyronine (T3) [25] and Tmod1 (tropomodulin 1), a gene encoding a ...
thyrotropin (TSHR) is one of the most interesting of all hormone-binding sites because of its close association with common human diseases, including thyroid nodules and Graves' disease.42,46,56 This article focuses on active areas of research that are providing new insights into this elusive ...
E. Thyroid hormone receptor phosphorylation regulates acute fasting-induced suppression of the hypothalamic–pituitary–thyroid axis. Proc. Natl Acad. Sci. USA 118, e2107943118 (2021). Article CAS PubMed PubMed Central Google Scholar Wu, L. et al. AMP-activated protein kinase (AMPK) regulates ...
The interaction between PARP1 and verminoside was selected as a standard to investigate the action mode of PARP1 with TPP. The molecular structures of TPP and verminoside (PARP1 agonist) were drawn by ChemDraw Ultra. The conformation changes and activation mechanism of PARP1 were explored by...
Bianco AC & Kim BW 2006 Deiodinases: implications of the local control of thyroid hormone action. Journal of Clinical Investigation 116 2571–2579. (doi:10.1172/JCI29812). PubMed Search Google Scholar Export Citation Bommer M, Kunze C, Fesseler J, Schubert T, Diekert G & Dobbek H 2014 ...
et al. New insights into the genic and metabolic characteristics of induced pluripotent stem cells from polycystic ovary syndrome women. Stem Cell Res Ther 9, 210 (2018). https://doi.org/10.1186/s13287-018-0950-x Download citation Received27 March 2018 Revised02 July 2018 Accepted04 July ...
This vicious cycle involves the joint action of CTCs, the resident cells in bone PMN, and their secreted factors. Tumor-derived factors, such as PTHrP, Dickkopf-1 (DKK-1), IL-8, TNF, TGF-β, and HPSE, can activate osteoclast maturation and promote bone resorption by receptor activator fo...
To be more detailed, we have probably detected effects on different genes at specifically developmental stages, as LiCl did not act directly on its target genes, but through the action of other genes belong- ing to the same functional pathway. Taking this into account, future efforts will ...