A separate search of 32 drugs was conducted at www.Clinicaltrials.gov to screen out the most recent studies related to DKD. All results are presented in the form of narrative reviews in this review. 3. The pathogenesis of DKD The main pathological changes of DKD were glomerular hypertrophy, ...
This paper describes the development and testing of a new screen for substance-related comorbidity, the 12-item DrugCheck Problem List (PL). Exploratory factor analysis with inpatient samples suggested a single-factor structure, although confirmatory factor analysis in a further sample found similar ...
Thirdly, we discover two factors that play a crucial role in a predictive framework: (1) the drug portfolio size of the company, indicating the greater susceptibility to an announcement in the case of low diversification among drug products and (2) the announcement network effect, manifesting ...
candidates for both study and treatment.39 VENETOCLAX (FORMERLY REFERRED TO AS ABT-199; ABBVIE; ABBOTT AND GENENTECH, NORTH CHICAGO, IL, USA) Mechanism of action Venetoclax (ABT-199) is a potent, selective oral drug that specifically acts to inhibit Bcl-2, a well-known regulator of ...
In addition, the present invention includes the steps of (i) selecting and targeting brain neurons involved in a specific behavior or disease; (ii) administering the drug to an animal model in which a fiber photometry device is inserted into target neurons in the brain; (iii) observing ...
Ma, L. et al. CRISPR–Cas9-mediated saturated mutagenesis screen predicts clinical drug resistance with improved accuracy.Proc. Natl Acad. Sci. USA114, 11751–11756 (2017). CASPubMedPubMed CentralGoogle Scholar Liang, J. R. et al. A genome-wide ER-phagy screen highlights key roles of mito...
Thus, it is not as widely used as oseltamivir, the only orally administered drug among the above three approved agents. Oseltamivir is a prodrug, which quickly converts to the active form, oseltamivir carboxylate (GS4071), by an esterase-catalyzed hydrolysis reaction inside the body28. The ...
Drug Development Abbreviations ETC: Electron transport chain OxPhos: Oxidative phosphorylation 2-OGDH: 2-Oxoglutarate dehydrogenase complex References Abdel-aleem S, el-Merzabani MM, Sayed-Ahmed M, Taylor DA, Lowe JE (1997) Acute and chronic effects of adriamycin on fatty acid oxidation in is...
Hearing loss is the most common form of sensory impairment in humans and affects more than 40 million people in the United States alone. No drug-based therapy has been approved by the Food and Drug Administration, and treatment mostly relies on devices such as hearing aids and cochlear implants...
Close Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma. Email address Sign up I agree my information will be processed in accordance with the Nature and Springer Nature Limited Privacy Policy....