Drug repurposing screen identifies lonafarnib as respiratory syncytial virus fusion protein inhibitor There is a need for effective antiviral drugs against RSV infection. Conducting an RSV repurposing screen using the ReFRAME library Sake et al. identify lonafarnib as an RSV fusion protein inhibitor, ch...
We report here an unbiased, repositioning screen using a bichromatic SSFR designed to mimic the splicing ratio of VEGF-Axxxa to VEGF-Axxxb isoforms. We have found a series of molecules, called ESSOs (named after the researchers’ initials), that have been shown, upon validation, to have an...
(e.g., benzodiazepines), make it increasingly difficult to manufacture a single assay to confidently screen for all target substances without compromising selectivity; (3) subjective results: while manufacturers recommend to interpret the presence of a test line, regardless of its intensity, as a ...
An earlier solid form screen would also have prevented the repeat of major studies late in development, as seen when atorvastatin Form I was found. Screening studies do not guarantee that all forms have been found, but they have significantly reduced the risk for most programs. The patents ...
We report a case of hyponatremia associated with non-psychogenic polydipsia and an overdose of an herbal diuretic, uva ursi in preparation for a routine workplace drug screen.关键词: arbutin hyponatremia polydipsia rhabdomyolysis uva ursi water intoxication ...
of banknotes being dropped on the floor; and the bottom right screenshot shows a young man holding a bundle of banknotes accompanied by the caption, “Gang gang.” Fig. 1 Young people displaying the money that could be made from drug distribution...
Non-alcoholic steatohepatitis (NASH) is a liver disease currently lacking an approved therapy, resulting in significant clinical demand. Traditional Chinese medicines (TCMs) have been commonly used to manage NASH. This study aimed to systematically analy
Finally, the model was used to screen a virtual compound database of commercially available compounds. A number of compounds found via virtual screening were tested and displayed statistically significant BSEP inhibition, ranging from 13± 1% to 67 ± 7% of control (P < 0.05) [48]. A ...
A high-throughput screen against pantothenate synthetase (PanC) identifies 3-biphenyl-4-cyanopyrrole-2-carboxylic acids as a new class of inhibitor with activity against Mycobacterium tuberculosis. PloS One 8, e72786 (2013). Article ADS CAS PubMed PubMed Central Google Scholar Patil, K., Bagade...
In a screen of 3630 small molecules, we identified the serotonin (5-hydroxytryptamine or 5-HT) receptor antagonist metitepine as a potent anorectic drug. Using cell-based assays we show that metitepine is an antagonist of all five Drosophila 5-HT receptors. We screened fly mutants for each...