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2009). In present day cases, a solid form screen should be performed in early development to find a suitable form long before Phase 3 clinical trials. An earlier solid form screen would also have prevented the repeat of major studies late in development, as seen when atorvastatin Form I was...
What are the odds of finding a COVID-19 drug from a lab repurposing screen? J. Chem. Inf. Model. 60, 5727–5729 (2020). CAS PubMed Google Scholar Vincent, F. et al. Developing predictive assays: the phenotypic screening “rule of 3”. Sci. Transl. Med. 7, 293ps215 (2015). ...
& Acar, M. A high-throughput screen for yeast replicative lifespan identifies lifespan-extending compounds. Cell Rep. 21, 2639–2646 (2017). CAS PubMed PubMed Central Google Scholar Zimmermann, A. et al. Yeast as a tool to identify anti-aging compounds. FEMS Yeast Res. 18, foy020 (...
“These models allow developers to screen with significant throughput for the activity and potential side effects of drug products against key pathways as well as understand their pharmacokinetics early in the development program,” she says. “Crucially, they provide this information using viable human...
Identified during a high-throughput screen, PTC124 has been selected as the most potent readthrough promoting drug from over 800,000 compounds screened (Welch et al., 2007). PTC-RT stimulating efficiency of PTC124 was successfully demonstrated in animals (Goldmann et al., 2012; Welch et al....
J Biomol Screen, 17 (2012), pp. 448-459 View PDFView articleCrossrefView in ScopusGoogle Scholar 114 M Maroto, Y Fernandez, J Ortin, F Pelaez, MA. Cabello Development of an HTS assay for the search of anti-influenza agents targeting the interaction of viral RNA with the NS1 protein J...
Considering the screen process for lead compounds in drug discovery stage, more and more drug candidates moving into development stage are water insoluble, especially for oncology compounds. Based on drug aqueous solubility and permeability, drugs have been classified into four biopharmaceutical classes (...
An alternative methodology developed to screen compounds against Leishmania is the use of genetically modified parasites expressing reporter genes, such as green fluorescent protein (GFP) or luciferase. Many recombinant parasites carrying a reporter gene either as an episomal copy or genome-integrated are...
et al. HERG-Lite: a novel comprehensive high-throughput screen for drug-induced hERG risk. J. Pharmacol. Toxicol. Methods 52, 136–145 (2005). Article CAS PubMed Google Scholar Roden, D. M. Taking the 'idio' out of 'idiosyncratic': predicting torsades de pointes. Pacing Clin. ...