Massively parallel DNA and RNA sequencing approaches have generated data on thousands of breast cancer genomes. In this review, we consider progress largely from the perspective of new concepts and hypotheses raised so far. These include challenges to the multistep model of breast carcinogenesis and ...
Massively parallel DNA and RNA sequencing approaches have generated data on thousands of breast cancer genomes. In this review, we consider progress largely from the perspective of new concepts and hypotheses raised so far. These include challenges to th
LINEs of evidence: noncanonical DNA replication as an epigenetic determinant accumulated in the fields of replication timing, chromatin organization, and epigenetics, bringing together evidence that strongly supports two new concepts. Fir... E Belan - 《Biology Direct》 被引量: 20发表: 2013年 The ...
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In this Perspective, we describe the landscape of personalised approaches in precision oncology, we explore on a case-by-case basis the regulatory readiness gap for these emerging technologies, we summarise and assess novel regulatory concepts that have been proposed to close this gap, and we ...