2、作者评估了确保基于DNA甲基化的预测因子可靠性能所需的关键统计学问题,如数据驱动的特征选择、消除性能评估中的数据泄漏,以及使用可推广的、充分有效的训练样本。 布里斯托大学Caroline L. Relton教授课题组在国际知名期刊Nat Rev Genet在线发表题为“DNA methylation-based predictors of health:applications and statis...
DNA甲基化(DNA methylation)是一种生物过程,是DNA化学修饰的一种形式,能在不改变DNA序列的前提下改变 DNA 片段的活性、从而改变遗传表现,为表观遗传编码的一部分,是一种外遗传机制,对细胞的正常发育至关重要,因此,与人体的几乎全部病...
2月15日,Nature杂志以长文形式发表了德国海德堡大学医院、德国癌症研究中心等单位上百名科学家联合完成的题为“DNA methylation-based classification of central nervous system tumours”的论文,研究发现基于DNA甲基化数据的分析可以改善脑肿瘤的诊断。 近年来,肿瘤表观遗传学领域的快速发展,为肿瘤诊断分型提供了一种可...
④Targeted bisulfite sequencing identified a panel of DNA methylation-based biomarkers for esophageal squamous cell carcinoma (ESCC),DOI 10.1186/s13148-017-0430-7. ⑤Identification of Tissue-Specific DNA Methylation Signatures for Thyroid Nodu...
① Targeted bisulfite sequencing identified a panel of DNA methylation-based biomarkers for esophageal squamous cell carcinoma (ESCC),DOI 10.1186/s13148-017-0430-7 ② Identification of Tissue-Specific DNA Methylation Signatures for Thyroid Nodule Diagnostics,DOI: 10.1158/1078-0432.CCR-18-0841 ...
Targeted bisulfitesequencing identified a panel of DNA methylation-based biomarkers for esophagealsquamous cell carcinoma (ESCC),DOI10.1186/s13148-017-0430-7 Identification ofTissue-Specific DNA Methylation Signatures for Thyroid Nodule Diagnostics,DOI: 10.1158/1078-0432.CCR-18-0841 ...
Numerous studies have investigated such measures of biological aging based on DNA methylation and have found them to be associated with mortality, disease, and risk factors for disease. Although the biological significance of age acceleration measures is not yet fully characterized, they represent a ...
① Targeted bisulfite sequencing identified a panel of DNA methylation-based biomarkers for esophageal squamous cell carcinoma (ESCC),DOI 10.1186/s13148-017-0430-7 ② Identification of Tissue-Specific DNA Methylation Signatures for Thyroid Nodule Diagnostics,DOI: 10.1158/1078-0432.CCR-18-0841 ...
Targeted bisulfitesequencing identified a panel of DNA methylation-based biomarkers for esophagealsquamous cell carcinoma (ESCC),DOI10.1186/s13148-017-0430-7 Identification ofTissue-Specific DNA Methylation Signatures for Thyroid Nodule Diagnostics,DOI: 10.1158/1078-0432.CCR-18-0841 ...
This Review evaluates the progress of existing DNA methylation-based predictors, including the contribution of machine learning techniques, and assesses the uptake of key statistical best practices needed to ensure their reliable performance, such as data-driven feature selection, elimination of data ...