Fig. 2: Utility of DNA methylation-based prediction of BM development over stage-based prognostication. - 图片说明- 多变量Cox比例风险模型显示,表观基因组风险评分具有独立于临床因素(包括TNM癌症分期评分)的预后价值(n = 56)。带须触须的盒子显示HR和95% CI。- AUROC性能指标显示,在验证数据集(n = 42)...
布里斯托大学Caroline L. Relton教授课题组在国际知名期刊Nat Rev Genet在线发表题为“DNA methylation-based predictors of health:applications and statistical considerations”的论文。DNA甲基化数据已成为生物标记物开发的宝贵信息来源,因为与静态遗传风险评估不同,DNA甲基化与各种外源和内源性因素(包括环境风险因素和复杂...
Numerous studies have investigated such measures of biological aging based on DNA methylation and have found them to be associated with mortality, disease, and risk factors for disease. Although the biological significance of age acceleration measures is not yet fully characterized, they represent a ...
DNA甲基化(DNA methylation)是一种生物过程,是DNA化学修饰的一种形式,能在不改变DNA序列的前提下改变 DNA 片段的活性、从而改变遗传表现,为表观遗传编码的一部分,是一种外遗传机制,对细胞的正常发育至关重要,因此,与人体的几乎全部病...
④Targeted bisulfite sequencing identified a panel of DNA methylation-based biomarkers for esophageal squamous cell carcinoma (ESCC),DOI 10.1186/s13148-017-0430-7. ⑤Identification of Tissue-Specific DNA Methylation Signatures for Thyroid Nodu...
DNA methylation data have become a valuable source of information for biomarker development, because, unlike static genetic risk estimates, DNA methylation varies dynamically in relation to diverse exogenous and endogenous factors, including environmental risk factors and complex disease pathology. Reliable ...
3月14日,Nature杂志以长文形式发表了德国海德堡大学医院、德国癌症研究中心等单位上百名科学家联合完成的题为“DNA methylation-based classification of central nervous system tumours”的论文,研究发现基于DNA甲基化数据的分析可以改善脑肿瘤的诊断。 近年来,肿瘤表观遗传学领域的快速发展,为肿瘤诊断分型提供了一种可...
① Targeted bisulfite sequencing identified a panel of DNA methylation-based biomarkers for esophageal squamous cell carcinoma (ESCC),DOI 10.1186/s13148-017-0430-7 ② Identification of Tissue-Specific DNA Methylation Signatures for Thyroid Nodule Diagnostics,DOI: 10.1158/1078-0432.CCR-18-0841 ...
① Targeted bisulfite sequencing identified a panel of DNA methylation-based biomarkers for esophageal squamous cell carcinoma (ESCC),DOI 10.1186/s13148-017-0430-7 ② Identification of Tissue-Specific DNA Methylation Signatures for Thyroid Nodule Diagnostics,DOI: 10.1158/1078-0432.CCR-18-0841 ...
[4]. Lam, K., et al., DNA methylation based biomarkers in colorectal cancer: A systematic review. Biochim Biophys Acta, 2016. 1866(1): p. 106-20. [5]. Stirzaker C , Taberlay P C , Statham A L , et al. Mining cancer methylomes: prospects and challenges[J]. Trends in Genetics,...