Epigenetic mechanisms, such as DNA methylation, regulate tissue specific gene expression, they are responsive to lifestyle and diet and have been implicated in a number of disease states. We hypothesized that DNA methylation in selected genes is associated with the blood lipoprotein profile in an ...
Sean & Milekic, Maria & Rosoklija, Gorazd & Stankov, Aleksandar & Trencevsja-Ivanovska, Iskra & Brennand, Kristen & Ge, Yongchao & Dwork, Andrew & Haghighi, Fatemeh. (2017). In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content...
DNA methylation at CpG dinucleotides can significantly increase the rate of cytosine-to-thymine mutations and the level of sequence divergence. Although the correlations between DNA methylation and genomic sequence evolution have been widely studied, an unaddressed yet fundamental question is how DNA meth...
4. Xu, J., et al., Cellular Heterogeneity-Adjusted cLonal Methylation (CHALM) improves prediction of gene expression.Nat Commun, 2021. 12(1): p. 400. 5. Shi, J., et al., The concurrence of DNA methylation and demet...
Represented in this figure is each trend line summarizing the triple-interaction action of the chronological age (X axis, in years), the DNA-(de)methylation status of the MS-AFLP band (presence or absence, 1/0), with respect to the almond source clone evaluated. The slope of the lines ...
DNA methylation is an epigenetic mark that is associated with gene silencing. Novel high-throughput techniques have begun to generate much larger scale maps of DNA methylation than were previously available. The new information has broadly confirmed several conclusions that were based on analysis of sp...
8. Wang Y.Y., Chen X., Sheng Y., Liu Y., Gao S (2017). N6-adenine DNA methylation is associated with the linker DNA of H2A. Z-containing well-positioned nucleosomes in Pol II-transcribed genes inTetrahymena. Nucleic Acids Res.,45, 11594-116...
IR often precedes the onset of T2D, but the relationship between myoblast DNA methylation and IR or the age-related decline in glycaemic control is not known. To gain insight into the underlying gene regulatory mechanisms associated with IR, we used the Infinium Human MethylationEPIC BeadChip (...
Xu J, Xiong L, Yao J L, et al. Hypermethylation in the promoter regions of flavonoid pathway genes is associated with skin color fading during ‘Daihong’apple fruit development[J].Horticulture Research, 2024: uhae031. Zheng G, Hu S, Cheng S, et al. Factor of DNA methylation 1 affect...
DNA methylation is an inheritable DNA modification which refers to adding of a methyl group to 5-cytosine (C) to DNA catalyzed by DNA methyltransferase, such as DNMT3a, and DNMT3b to form 5-methylcytosine (5mC). From: Journal of Autoimmunity, 2017 ...