Here we report a distinctive gene-targeted RNA-directed DNA methylation (RdDM) activity in the Arabidopsis thaliana male sexual lineage that regulates gene expression in meiocytes. Loss of sexual-lineage-specific RdDM causes mis-splicing of the MPS1 gene (also known as PRD2), thereby disrupting ...
Focus on the bioinformatics analysis of DNAmethylation. 主要研究DNA甲基化的生物信息学分析. 互联网 Methylationof chromatin causes it to condense. 染色质甲基化后会出现凝缩. 互联网 Conclusion: P 15 genemethylationmight be related with the pathogenesis, and prognosis of MM. ...
The spatial arrangement and three-dimensional structure of DNA in the nucleus is controlled through the interdigitation of DNA binding proteins such as histones and their modifiers, the Polycomb- Trithorax proteins, and the DNA methyltransferase enzymes. DNA methylation forms the foundation of chromatin...
DNA methylationgenetic resourcesrDNASolanum tuberosumThe in vitro conservation of potato using tissue culture medium supplemented with the growth retardant mannitol causes morphological changes in the propagated material. These culture conditions seem to have an affect on the DNA extracted from the ...
Plasma cell-free DNA (cfDNA) are small molecules generated through a non-random fragmentation procedure. Despite commendable translational values in cancer liquid biopsy, however, the biology of cfDNA, especially the principles of cfDNA fragmentation, re
Epigenetic mechanisms, particularly DNA methylation, are a possible link between environmental and biological determinants of health. As the DNA methylome undergoes rearrangement in utero and is susceptible to environmental insults, it may be a mechanism explaining the developmental origins of human disease...
Retinitis pigmentosa (RP) defines a group of inherited degenerative retinal diseases causing progressive loss of photoreceptors. To this day, RP is still untreatable and rational treatment development will require a thorough understanding of the underlyi
DNA methylation is a stable epigenetic mark that can be inherited through multiple cell divisions. During development and cell differentiation, DNA methylation is dynamic, but some DNA methylation patterns may be retained as a form of epigenetic memory.
In the present paper, we have analyzed the mechanisms underlying cell type- and developmental stage-dependent responsiveness of the GFAP gene promoter to the gp130-STAT3 signal with respect to DNA methylation. We show that a CpG site in a particular STAT3 recognition sequence between −1518 and...
Aberrant methylation at the H19 paternal imprinted gene has been identified in different cohorts of infertile males. The causes of H19 methylation errors are poorly understood. In this study, we investigated the methylation status of the H19 gene in semen DNA samples from infertile males affected...