(Fig.2band Extended Data Fig.4a). The ability of diphenyleneiodonium chloride (DPI) to inhibit NET formation in cells from MICL-deficient animals revealed the dependence of this response on NADPH oxidase (Extended Data Fig.4c). MICL transduces intracellular inhibitory signals through SHP1/2 (ref...
neutrophil extracellular trap formation通路解释 中性粒细胞外围陷阱形成(neutrophil extracellular trap formation,NETosis)是一种特殊的中性粒细胞死亡方式,用于对抗细菌和其他病原体的感染。 NETosis过程包括以下几个步骤: 1.活化:中性粒细胞受到感染或其他刺激后,会经历一系列内部信号转导事件的激活,包括细胞膜上的...
neutrophil extracellular trap formation is independent of de novo gene expression.中性粒细胞胞外陷阱形成独立于新创的基因表达 热度: 中性粒细胞外捕获网(NETs)解析PPT 热度: 中性粒细胞外陷阱(nets)杀灭金黄色葡萄球菌及糖皮质激素对其影响的体外研究
Our results provide further evidence that autophagy is involved in ANCA‐induced NET formation in human neutrophils.doi:10.1111/cei.12589John Wiley & Sons, LtdClinical & Experimental ImmunologyTang S, Zhang Y, Yin SW, Gao XJ, Shi WW, Wang Y, et al. Neutrophil extracellular trap formation is ...
sustained inflammation or persistent stimuli can lead to excessive NET formation, thereby exacerbating tissue damage during inappropriate inflammation. Additionally, NET formation is observed in nonpathogenic conditions, including but not limited to sterile inflammation, autoimmune disorders, metabolic dysregulatio...
neutrophilextracellulartraps(NETs).NETsarereleasedbyPMNsaftertheactivationofaspe- cializedcelldeathpathwayandconsistofchromatinboundtocytoplasmicproteins[3,4,5]. MicroorganismsaswellaschemicalcompoundstriggerNETformation,however,themolecu- larmechanismleadingtoreleaseofNETsisonlypoorlycharacterized.ManyNETinducers trigger...
Understanding the specific mechanisms of NETosis and its interactions with other factors in the tumor microenvironment will help answer this question. Additionally, NETs can enrich mtDNA, and the oxidation state of mtDNA is closely related to NETs formation, but what are the specific regulatory mechan...
PMA and crystal-induced neutrophil extracellular trap formation involves RIPK1-RIPK3-MLKL signaling. Eur. J. Immunol. 46, 223–229 (2016). CAS PubMed Google Scholar Amini, P. et al. NET formation can occur independently of RIPK3 and MLKL signaling. Eur. J. Immunol. 46, 178–184 (...
NK cell depletion results in decreased NET formation and smaller thrombi suggesting that NK cells are required for thrombus development. In depleted mice, adoptive transfer of WT NK cells induced similar thrombosis burden as in WT mice. In contrast, adoptive transfer of IFNγ -/- NK cells ...
Pathways of Neutrophil Extracellular Trap Formation To date, three different pathways have been identified to mediate the formation of NETs. The best-known pathway is the conventional suicidal NETosis that generally lasts from 2 to 4 h.[ 2 ] Suicidal NETosis is initiated by the recognition of ...