dysregulation of NET release is protective during systemic infection with the fungal pathogenAspergillus fumigatus. Together, we show that the recognition of NETs by MICL represents a fundamental autoregulatory pathway that controls neutrophil activity and NET formation. ...
Neutrophil extracellular traps (NETs) are extracellular chromatin structures that can trap and degrade microbes. They arise from neutrophils that have activated a cell death program called NET cell death, or NETosis. Activation of NETosis has been shown to involve NADPH oxidase activity, ...
neutrophil extracellular trap formation通路解释 中性粒细胞外围陷阱形成(neutrophil extracellular trap formation,NETosis)是一种特殊的中性粒细胞死亡方式,用于对抗细菌和其他病原体的感染。 NETosis过程包括以下几个步骤: 1.活化:中性粒细胞受到感染或其他刺激后,会经历一系列内部信号转导事件的激活,包括细胞膜上的...
Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J. Cell Biol. 191, 677–691 (2010). CAS PubMed PubMed Central Google Scholar Metzler, K. D. et al. Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate ...
Extracellular-trap-formation-in-kuruma-shrimp-Marsupenaeus-japonicus-hemocytes-is-coupled-with-c-type-lysozyme_2016_Fish-Shellfish-Immunology 热度: the function(s) provided by the adenovirus-specified, dna-binding protein required for viral late gene expression is independent of the role of the ...
TcpC is a multifunctional virulence factor of uropathogenic E. coli (UPEC). Neutrophil extracellular trap formation (NETosis) is a crucial anti-infection mechanism of neutrophils. Here we show the influence of TcpC on NETosis and related mechanisms. We s
Neutrophil extracellular traps (NETs) — formation and :中性粒细胞外的陷阱(网)的形成和 热度: 中性粒细胞胞外网状陷阱 热度: 多肌炎中性粒细胞胞外陷阱特征 热度: 相关推荐 RESEARCHARTICLE NeutrophilExtracellularTrapFormationIs IndependentofDeNovoGeneExpression GabrielSollberger* ☯ ,BorkoAmulic* ☯...
可溶性NET是中性粒细胞在PMA[3]刺激下,结合PKC和RAF-MEK-MARK信号通路,使NADPH酶激活释放氧自由基(ROS),从而激活肽基精氨酸脱亚胺酶4(peptidyl arginine deiminase 4,PAD4)使组蛋白上精氨酸正电消失,并转化为瓜氨酸,导致DNA和组蛋白间电荷破坏,染色质解体。解体的染色质和颗粒蛋白释放到细胞外空间形成NET,其中,RO...
TcpC is a multifunctional virulence factor of uropathogenic E. coli (UPEC). Neutrophil extracellular trap formation (NETosis) is a crucial anti-infection mechanism of neutrophils. Here we show the influence of TcpC on NETosis and related mechanisms. We s
Since we had observed that neutrophils and other granulocytes release mitochondrial DNA (mtDNA) in the formation of extracellular DNA traps3, we hypothesized that mitochondrial dynamics might be important for mtDNA release. Five members of the GTPase dynamin family, namely mitofusin-1 (MFN1), mitofusi...