neutrophil extracellular trap formation通路解释 中性粒细胞外围陷阱形成(neutrophil extracellular trap formation,NETosis)是一种特殊的中性粒细胞死亡方式,用于对抗细菌和其他病原体的感染。 NETosis过程包括以下几个步骤: 1.活化:中性粒细胞受到感染或其他刺激后,会经历一系列内部信号转导事件的激活,包括细胞膜上的...
dysregulation of NET release is protective during systemic infection with the fungal pathogenAspergillus fumigatus. Together, we show that the recognition of NETs by MICL represents a fundamental autoregulatory pathway that controls neutrophil activity and NET formation. ...
(2016)NeutrophilExtracellular Trap Formation Is Independent of De Novo Gene Expression. PLoS ONE 11(6): e0157454. doi:10.1371/journal. pone.0157454 Editor: Dominik Hartl, University of Tübingen, GERMANY Received: February 16, 2016 Accepted: May 31, 2016 Published: June 16, 2016 Copyright: ©...
Besides intracellular killing, neutrophils are able to exert an antibacterial activity in the extracellular space by the formation of so-called neutrophil extracellular traps (NETs)1,2. NETs consist of DNA and granule proteins and are able to bind and to kill extracellular pathogens. Thus, NETs re...
(2016)NeutrophilExtracellular Trap Formation Is Independent of De Novo Gene Expression. PLoS ONE 11(6): e0157454. doi:10.1371/journal. pone.0157454 Editor: Dominik Hartl, University of Tübingen, GERMANY Received: February 16, 2016 Accepted: May 31, 2016 Published: June 16, 2016 Copyright: ©...
TcpC is a multifunctional virulence factor of uropathogenic E. coli (UPEC). Neutrophil extracellular trap formation (NETosis) is a crucial anti-infection mechanism of neutrophils. Here we show the influence of TcpC on NETosis and related mechanisms. We s
COPD is a progressive disease of the airways that is characterized by neutrophilic inflammation, a condition known to promote the excessive formation of neutrophil extracellular traps (NETs). The presence of large amounts of NETs has recently been demonstrated for a variety of inflammatory lung diseas...
Superoxide Induces Neutrophil Extracellular Trap Formation in a TLR-4 and NOX-Dependent Mechanism Ahmed B Al-Khafaji,1 Samer Tohme,1 Hamza Obaid Yazdani,1 David Miller,2 Hai Huang,1,3 and Allan Tsung1 1Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh; Pennsylvania, ...
Neutrophil elastase and myeloperoxidase regulate the formation of neutrophil extracellular traps. J. Cell Biol. 191, 677–691 (2010). CAS PubMed PubMed Central Google Scholar Metzler, K. D. et al. Myeloperoxidase is required for neutrophil extracellular trap formation: implications for innate ...
TcpC is a multifunctional virulence factor of uropathogenic E. coli (UPEC). Neutrophil extracellular trap formation (NETosis) is a crucial anti-infection mechanism of neutrophils. Here we show the influence of TcpC on NETosis and related mechanisms. We s