neutrophil extracellular trap formation通路解释 中性粒细胞外围陷阱形成(neutrophil extracellular trap formation,NETosis)是一种特殊的中性粒细胞死亡方式,用于对抗细菌和其他病原体的感染。 NETosis过程包括以下几个步骤: 1.活化:中性粒细胞受到感染或其他刺激后,会经历一系列内部信号转导事件的激活,包括细胞膜上的...
neutrophilextracellulartrapformationisindependentofdenovogene 系统标签: neutrophilextracellularnovoformationtrap粒细胞 RESEARCHARTICLENeutrophilExtracellularTrapFormationIsIndependentofDeNovoGeneExpressionGabrielSollberger*☯,BorkoAmulic*☯,ArturoZychlinskyDepartmentofCellularMicrobiology,MaxPlanckInstituteforInfectionBiology,...
neutrophilextracellularnovoformationtrap粒细胞 RESEARCHARTICLE NeutrophilExtracellularTrapFormationIs IndependentofDeNovoGeneExpression GabrielSollberger* ☯ ,BorkoAmulic* ☯ ,ArturoZychlinsky DepartmentofCellularMicrobiology,MaxPlanckInstituteforInfectionBiology,Berlin,Germany ☯Theseauthorscontributedequallytothiswork...
Since we had observed that neutrophils and other granulocytes release mitochondrial DNA (mtDNA) in the formation of extracellular DNA traps3, we hypothesized that mitochondrial dynamics might be important for mtDNA release. Five members of the GTPase dynamin family, namely mitofusin-1 (MFN1), mitofusi...
NET formation was found after exposure of wild-type and receptor for advanced glycation end products-deficient neutrophil to HMGB1, whereas deficiency of Tolllike receptor (TLR)4 diminished the ability of neutrophils to produce NETs. Incubation of neutrophils with HMGB1 significantly increased the ...
Recent evidence suggests that enhanced neutrophil extracellular trap (NET) formation activates plasmacytoid dendritic cells and serves as a source of autoa... JS Knight,W Zhao,W Luo,... - 《Journal of Clinical Investigation》 被引量: 211发表: 2013年 Efficient Neutrophil Extracellular Trap Induction...
TcpC is a multifunctional virulence factor of uropathogenic E. coli (UPEC). Neutrophil extracellular trap formation (NETosis) is a crucial anti-infection mechanism of neutrophils. Here we show the influence of TcpC on NETosis and related mechanisms. We s
In response to antineutrophil cytoplasmic antibody (ANCA), activated neutrophils release decondensed chromatin associated with cytoplasmic granular proteins composed of proteolytic enzymes and myeloperoxidase (MPO); these complexes are named neutrophil extracellular traps (NETs). NET formation requires peptidylarg...
中性粒细胞的一个关键特征是它们能够将一种被称为中性粒细胞胞外陷阱(neutrophil extracellular trap,NET)的结构挤压到周围环境中。NET是一种由被有毒性的酶覆盖的DNA组成的网状结构,正常情况下能够捕获并杀死入侵的微生物。然而,越来越多的证据表明,NET介导了癌细胞侵袭特性的发展和增强,但它们是如何促进癌细胞转移的...
Neutrophil extracellular trap formation was determined using the colorimetric NET formation Assay Kit from Cayman Chemicals based on the enzymatic activity of NET-associated neutrophil elastase. PMNs from various healthy donors were isolated as described above and stimulated with RNA-LL37 complex, or PMA...