These findings are discussed in relation to the Marrack-Heidelberger-Goldberg concept of the formation of massive specific aggregates between antigen and antibody.doi:10.1016/0042-6822(62)90029-6Bradish, C.J.Farley, Jacqueline O.Ferrier, Helen E.N....
2. The principal target for development of effective antibody-based antiviral approaches is the viral Spike glycoprotein3,4,5. In the Spike trimer, the three receptor-binding domains (RBDs)
People with deficiencies in their immune system often have an insufficient antibody response to antigens such as bacteria, viruses, or vaccines. These patients therefore often receive antibodies from healthy people to replace the missing antibodies and build a first line of defense against infections....
Secondary memory responses would be expected to (1) be of higher titer than primary responses, (2) arise more rapidly than primary responses, and (3) neutralize both the priming and boosting antigens (Ahmed and Gray, 1996). To determine if the nAb responses to superinfection were elevated, ...
Antibodies are the products of the adaptive humoral immune response; the molecules they recognize are called antigens; the molecules that elicit the antibody response are immunogens. Hence some proteins, particularly foreign ones, are both immunogens, inducing the production of specific antibodies again...
Neutralization effects of antibody elicited by chimeric HBV S antigen viral-like particles presenting HCV neutralization epitopes Neutralization effects of antibody elicited by chimeric HBV S antigen viral-like particles presenting HCV neutralization epitopes EpitopesHepatitis C virus... S Wei,Y Lei,J ...
The presence of maternally derived antibodies can interfere with the development of an active antibody response to antigen. Infection of seven passively im... M Lemaire,V Weynants,J Godfroid,... - 《Journal of Clinical Microbiology》 被引量: 138发表: 2000年 Structure-guided Alterations of the ...
A mature SARS-CoV-2 has four structural proteins: envelope (E), membrane (M), nucleocapsid (N), and spike that can be target antigens to induce neutralizing antibody and T-cell responses2. The spike protein is expressed on the surface of the virus, and contains the receptor-binding ...
We measured focus size (in the absence of neutralizing antibody), where one focus forms when the infection is spread from one infected cell to surrounding cells (Fig. S3). In Vero-TMPRSS2 cells, we found that both BA.2.86 and XBB.1.5 made infection foci which were 5-fold and 4.5-fold...
Chikungunya Virus Neutralization Antigens and Direct Cell-to-Cell Transmission Are Revealed by Human Antibody-Escape Mutants.doi:10.1371/journal.ppat.1002390Chikungunya virus (CHIKV) is an alphavirus responsible for numerous epidemics throughout Africa and Asia, causing infectious arthritis and reportedly...