Reagents which regulate human neuropeptide Y-like G protein-coupled receptor (NPY-like GPCR) protein and reagents which bind to human NPY-like GPCR gene products can play a role in preventing, ameliorating, or correcting dysfunctions or diseases including, but not limited to, obesity, diabetes, ...
The present invention relates to polynucleotide and polypeptide molecules for zpep17, a novel secreted protein. The polynucleotides encoding zpep17, may, for example, be used to identify a region of the genome associated with human disease states. The present invention also includes methods for pr...
Analysis of the adaptor protein profile of the material eluting from the Sephacryl S-1000 column demonstrates a wide distribution of the Golgi-associated AP-1 (HA-I) molecules (AP47 and AP19) in relation to the CCV peak, spanning both the ascending and descending portions of the CCV peak...
identified as the endogenous ligands of a G-protein-coupled orphan receptor, SENR (sensory epithelium neuropeptide-like receptor), which is identical to ... M Mori,T Sugo,M Abe,... - PubMed 被引量: 178发表: 1999年 The distribution of neuropeptide Y-like immunoreactive neurons in the human...
The unfolded protein response is activated in Alzheimer's disease Accumulation of misfolded proteins in the endoplasmic reticulum triggers a cellular stress response called the unfolded protein response (UPR) that protect... JJM Hoozemans,ESV Haastert,DAT Nijholt,... - 《American Journal of Patholog...
Dynamics of ECT normalization of low G protein function and immunoreactivity in mononuclear leukocytes of patients with major depression. Heterotrimeric G proteins were previously implicated in the biochemical mechanisms underlying the pathophysiology and treatment of mood disorders. Low func... S Avissar,...
ORPHANIN FQ - A NEUROPEPTIDE THAT ACTIVATES AN OPIOIDLIKE G PROTEIN-COUPLED RECEPTOR 1995. orphanin FQ; a neuropeptide that activates an opioid like G protein-coupled receptor. Science 270: 792-794Reinscheid;RK;Nothacker;HP;Bourson;A;... RK Reinscheid,HP Nothacker,A Bourson,... - 《Sci...
Specificity of the NPY antibody was verified with colocalization of green fluor- escent protein (GFP) and NPY (495%) in NPY-sappphire- GFP transgenic mice (Pinto et al, 2004). NPY and Y1R IR were visualized using standard 3,30-diamino-benzidine (DAB) procedures that we have described ...
Establishment of NPY-knockout zebrafish. (A) The target sequence of guide RNAs (gRNAs) for zebrafishnpy. Protein-coding exons are indicated as black boxes. Protospacer-adjacent motif (PAM) sequences are underlined. (B) F0 founder genotyping. An asterisk indicates the induction of heteroduplexes...
Calcitonin receptor-like (CALCRL) is a G-protein-coupled neuropeptide receptor involved in the regulation of blood pressure, angiogenesis, cell proliferation, and apoptosis, and is currently emerging as a novel target for the treatment of migraine. This study characterizes the role of CALCRL in acut...