Muscle Contraction Summary Nerve impulse reaches neuromuscular junction Acetylcholine is released from motor neuron Ach binds with receptors in the muscle membrane to generate signal in the sarcolemma Muscle Contraction (Cont’d) Activation signal travels down T tubule Sarcoplamic reticulum releases calcium...
preserving muscle size, function, and neuromuscular junction (NMJ) integrity. Interestingly, responsiveness to rapamycin differs between muscles, suggesting that the primary drivers of age-related muscle loss may differ between muscles. To dissect the key signaling nodes associated with...
(A) Wild-type neuromuscular junction of a mouse expressing thy1-CFP transgene in α-motor axons and tdTomato in SCs. (B) One week post-tSC ablation. The motor axon and SCs were transgenically labeled with CFP and tdTomato, respectively. Note that the natural overlying tSC label is ...
The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle.Front Aging Neurosci.2014;6:208. 10. Punga AR and Ruegg MA. Signaling and aging at the neuromuscular synapse: lessons learnt from neuromuscular diseases.Curr Opin Pharmacol.2012;12:340-346.. 11. Vandervoort AA. ...
Both the actin cable network and the adhesive ring, labeled by myosin IIA and vinculin, respectively, were located outside of the Dyn2 belt (Figures 1C, S1C, and S1D). Localization of the belt-shaped Dyn2 structure around the actin core was confirmed by stimulated emission depletion (STED...
Representative images of sections from iliopsoas stained with H&E (A–A″), immunolabeled for MHC type I (brown) and II (pink) (B–B″), and stained for COX/SDH activity (C–C″) highlight the patchy nature of the disease process; affected fascicles are surrounded by unremarkable ...
Considering the direction of Wallerian degeneration from the nerve injury site to the distal innervated muscle, the cuff electrode is implanted as distal as possible, in order to trigger effective neuromuscular junction stimulation via a remaining conductive nerve. The rationale for this strategy follows...
Our daily life depends on muscle contraction, a process that is controlled by the neuromuscular junction (NMJ). However, the mechanisms of NMJ assembly remain unclear. Here we show that Rapsn, a protein critical for NMJ formation, undergoes liquid-liquid phase separation (LLPS) and condensates ...
Loss of function mutations in kis and animals expressing human APP and BACE in their central nervous system show reductions in the glutamate receptor subunit, GluRIIC, the GTPase Rab11, and the bone morphogenetic protein (BMP), pMad, at the Drosophila larval neuromuscular junction (NMJ). ...