preserving muscle size, function, and neuromuscular junction (NMJ) integrity. Interestingly, responsiveness to rapamycin differs between muscles, suggesting that the primary drivers of age-related muscle loss may differ between muscles. To dissect the key signaling nodes associated with...
The Drosophila larval neuromuscular junction (NMJ) consists of a presynaptic motor neuron terminal and a postsynaptic muscle cell that offer an accessible and popular model system for the analysis of synaptic growth and function. I describe techniques for visualizing fluorescently labeled proteins within ...
The Neuromuscular Junction: Aging at the Crossroad between Nerves and Muscle.Front Aging Neurosci.2014;6:208. 10. Punga AR and Ruegg MA. Signaling and aging at the neuromuscular synapse: lessons learnt from neuromuscular diseases.Curr Opin Pharmacol.2012;12:340-346.. 11. Vandervoort AA. ...
It is unlikely that membrane-associated MuSK binds directly to nuclear Syne-1 because MuSK is concentrated at the crests of the ∼1 μm-deep junction folds whereas nuclei lie beneath the folds. However, MuSK might be translocated to the nucleus under some circumstances or low levels of Syne...
Upper, Sashimi plot showing the normalized exon-exon junction reads over the dPix locus in one sample of each genotype. Middle, diagram illustrating the numbering of the exons and exon segments of dPix. Red exons are specific to isoforms F, H and I, and blue exons are specific to isoforms...
1977. Cytochemical localization of acetylcholine receptors at the neuromus- cular junction by means of horseradish peroxydase-labeled a-bungaro- toxin. Brain Res. 132:423-442.Lentz, T. L., J. E. Mazurkiewicz, and J. Rosenthal (1977) Cytochemical localization of acetylcholine re...
VAP-33 localizes to both an intracellular vesicle population and with occludin at the tight junction J. Cell Sci., 112 (1999), pp. 3723-3732 Google Scholar Laurent et al. 2000 F. Laurent, G. Labesse, P. de Wit Molecular cloning and partial characterization of a plant VAP33 homologue ...