The paper is organized as follows. Section “TheNETMEmodel” introducesNETMEsystem together with its components. Section “The annotation tool” provides the technical details of the back-end and the front-end ofNETME. Section “Experimental analysis” reports two different case studies that allow ...
We also assessed the effect of shear stress on neutrophil responses to three other NET-inducing agents, PMA, LPS and ATP. Among these stimuli, ATP is generated abundantly in the cytosol through respiration and glycolysis pathways49. Extracellularly, ATP acts as autocrine and paracrine signalling mo...
Rotundic acid improves nonalcoholic steatohepatitis in mice by regulating glycolysis and the TLR4/AP1 signaling pathway Article Open access 04 December 2023 Andrographolide Ameliorates Inflammation and Fibrogenesis and Attenuates Inflammasome Activation in Experimental Non-Alcoholic Steatohepatitis Article Open...
First, many network inference methods rely on correlations of gene expression data, yet the actual transcriptional activities of many master regulators may not be reflected in their gene expression. Instead, the activity may be better associated with either their protein level, the level of a certa...
(B) Steady-state flux J glycolysis , as a function of the Michaelis-Menten constant of the glucose transporter KM,GLT, of a kinetic model of S. cerevisiae glycolysis. At an extracellular glucose concentration of 110 mM (green line) the low affinity HXT3 transporter (K M = 34 mM) ...
The presence of the ATP-ADP system in both the networks could be explained considering that ATP is the main energetic source of spermatozoa. In fact in this cell, the metabolic energy production is fuelled by the glycolysis exclusively, by mitochondrial oxidative phosphorylation exclusively, or by ...
MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages. Cell Rep. 2021;35:109264. S u et al. Genome Biology (2022) 23:270 Page 21 of 21 67. Hu X, Ivashkiv LB. Cross-regulation of signaling pathways ...
Figure 1. Diagram of the role of carbohydrate metabolism disorder in atherosclerosis development and progression. 1.2.1. Glycolytic Pathway The glycolytic pathway, known as glycolysis (see Figure 1), is a fundamental metabolic pathway that occurs in the cytoplasm of cells. It serves as a central...
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Insulin secretion is tightly regulated by blood glucose levels through a series of well-coordinated steps. Glucose enters beta cells via glucose transporter type 2 and is metabolized through glycolysis and the citric acid cycle, leading to an increase in the ATP/ADP ratio. This metabolic shift ...