Neoantigen load, antigen presentation, immune profile and their relevance to clinical outcomes were also investigated.Results: Either BRCA1/2, RAD51C/D mutations, or BRCA1, RAD51C promoter methylation was defined as HR-deficient. A total of 34 (42.5%) and 46 (57.5%) patients were classified...
Intron retention-induced neoantigen load correlates with unfavorable prognosis in multiple myeloma Article Open access 09 September 2021 Immunogenicity and therapeutic targeting of a public neoantigen derived from mutated PIK3CA Article Open access 28 April 2022 Proteogenomic discovery of neoantigens fac...
Lauss M, Donia M, Harbst K, Andersen R, Mitra S, Rosengren F, Salim M, Vallon-Christersson J, Torngren T, Kvist A, Ringner M, Svane IM, Jonsson G (2017) Mutational and putative neoantigen load predict clinical benefit of adoptive T cell therapy in melano- ma. Nat Commun 8:1738...
Does the Neoantigen Load or Immune Phenotype Correlate With ICI Responses in Lung Cancer? ICI used in lung cancer such as anti–PD-1, anti-PD-L1 and anti–CTLA4 antibodies relies principally on blocking the immune checkpoints, thereby removing the “brakes” on established immune responses. Axio...
Here, we quantify IR-neoAg in pancreatic cancer and evaluate whether IR-neoAg load might serve as a biomarker for selecting patients who may benefit from ICB therapy. Methods:We developed a computational approach to estimate patient-specific IR-neoAg load from transcriptome data available in The...
Our study draws a preliminary conclusion that it is not TMB or neoantigen load but the TP53 specific neoantigen is related to overall survival of HCC patients. We suggest that the TP53 neoantigen may affect prognosis by regulating anti-tumor immunity and that the TP53 neoantigen may be harnessed...
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NJ-load-specific differential gene analysis TCGA LGG and GBM samples were ranked according to the total putative NJs expressed per sample. High (NJHI) and low (NJLO) NJ load samples in each disease subtype were characterized as the upper and lower 0.10 percentile of ranked samples, respectively...
In addition, advances like next-generation sequencing have identified several genetic biomarkers—such as mismatch DNA repair—that measure high neoantigen load, they noted. “Recent success of ICIs in tumors with high tumor mutational burden (TMB), which is a measurement of cancer neoantigens and ...
f, Clonal neoantigen load and immune-infiltration classification are incorporated in a multivariate analysis: this combination is more significant as a predictor of prognosis than either metric individually. Other tumour and clinical characteristics are also controlled for in the multivariate analysis. ...