(dba)3are found in a vast majority of reported examples. Pd(AcO)2or the well-defined PEPPSI-IPr precatalyst have also been profusely used(125). The lack of references to palladacycles as the catalysts of choice for the Negishi coupling in the consulted key review documents(1b, 2b, 3d, ...
However, no examples of their use in the Negishi coupling have been 君,已阅读到文档的结尾了呢~~ 立即下载 相似精选,再来一篇 更多 喜欢该文档的用户还喜欢 Multiple Pairwise Analysis of Non-homologous Centromere Coupling Reveals Preferential Chromosome Size-Dependent Interactions and a Role for Bouquet...
Cross-couplingPalladiumDiazonium salts, precisely arenediazonium o-benzenedisulfonimides, have been used for the first time as efficient electrophilic partners in Negishi coupling reactions. The synthetic protocol was general, easy and gave biaryls in satisfactory yields (34 examples, average yield 69%...
In these examples, an overall cross coupling between two π-components is achieved. Upon securing his position as full professor at Purdue in 1979, and with thoughts of returning to Japan behind him, Negishi settled to the task of achieving pair-selectivity and practical use for the coupling. ...
A continuous-flow method for the regioselective arylation of fluoroarenes and fluoropyridines has been developed. The telescoped procedure reported here consists of a three-step metalation, zincation, and Negishi cross-coupling sequence, providing efficient access to a variety of functionalized 2-fluoro...
Herein, we describe an approach to alkyl‐ketones bearing glycal units via the Pd‐catalyzed carbonylative coupling of 2‐iodoglycals and alkyl and aryl halides. Examples bearing a variety of functional groups are presented as well as a mechanistic proposal for this transformation....
Herein, we describe an approach to alkyl﹌etones bearing glycal units via the Pdヽatalyzed carbonylative coupling of 2﹊odoglycals and alkyl and aryl halides. Examples bearing a variety of functional groups are presented as well as a mechanistic proposal for this transformation. A versatile C(...
cobaltNegishi cross-couplingα-bromo esterAn environmentally benign and high functional-group-tolerant synthesis of α-arylalkanoic esters was found. This is the first cobalt-catalyzed enantioselective Negishi cross-coupling reaction, and the first arylation of α-halo esters with arylzinc halides. ...
The first method for the stereoconvergent cross-coupling of racemic a-halonitriles is described, specifically, nickel-catalyzed Negishi arylations and alkenylations that furnish an array of enantioenriched a-arylnitriles and allylic nitriles, respectively. Noteworthy features of this investigation include...
Negishi cross‐coupling on pyrrolopyrimidine 36 was performed using a selection of substituted benzyl bromides with Pd(PPh3)4 as catalyst in THF at 60 °C (Scheme 4). To facilitate zinc insertion to the fluorinated analogues, LiCl was used as an additive. The concentration of the ...