1). Combining the chemistry developed here with the regulation of hydrogel actuation5,37,38,53,54,55, self-assembly56,57, and liquid–liquid phase separation58 will lead to materials with complex programmable responses59,60. Methods Synthesis For the complete synthetic procedures of compounds 2–...
Infants admitted to the neonatal intensive care unit, particularly those born preterm, are at high risk for infection due to the combination of an immature immune system, prolonged hospitalization, and frequent use of invasive devices. Emerging evidence suggests that multidrug-resistant gram-negative (...
The epithelial cells of the normal intestinal tract do not express TLR4 [46, 47 ]. This is probably the consequence of evolution following millennia of cohabitation with gram-negative bacteria in the intestinal tract, which provide a vast source of LPS; the mechanism of “negative regulation” ...
Several possible mechanisms for age-related muscle atrophy have been described; however, the precise contribution of each is unknown. Age-related muscle loss is a result of reductions in the size and number of muscle fibers [23] possibly due to a multifactorial process that involves physical activ...
It posits that a system or organism maintains stability and resilience by having multiple inter-related and redundant mechanisms for responding to insults. When there are too few overlapping resiliency mechanisms or when mechanisms fail then the capacity of the system to resist or respond is ...
there is little information regarding the factors responsible for maintenance of the Pol II pause during the early hours of development. Our present study brings forth new insights by describing the role of NELF in transcriptional regulation of one of the central groups of genes inDrosophiladevelopmen...
can be divided into four categories: (1) modifying the secretion tag that targets a protein for secretion; (2) engineering the secretion system machinery; (3) transferring a secretion system to a more desirable production strain; and (4) manipulating the genetic regulation of the secretion ...
In addition, the upregulation of genes upon PLK1 inhibition correlates with their expression in normal breast tissue and with better overall survival in breast cancer patients. Our results indicate that differentiation therapy based on PLK1 inhibition is a potential alternative strategy to treat TNBC....
process, the coagulation factors are cleaved to form two chains, including a light chain (LC) and a heavy chain (HC), which are connected to each other by a single disulfide bond. The HC possesses serine protease activity, whereas the LC consists of a γ-carboxyglutamic acid domain (Gla)...
Based on the stimulus-organism-response (S-O-R) theory, this paper aims to address the following research questions: 1. Is the valuation of FT food products a stimulus for greater willingness to pay? 2. Do consumer emotions mediate the relationship between the valuation of FT food products ...