Integrins in human T cell function: Transdominant regulation, conformational constraints, and intracellular effectors Integrin adhesion molecules have both positive and negative potential in the regulation of peripheral blood T cell (PB T cell) activation, yet their mechanism of action in the mediation ...
Pepper MS. Positive and negative regulation of angiogenesis: from cell biology to the clinic. Vasc Med. 1996;1:259 -266.Pepper MS.Positive and negative regulation of angiogenesis: From cell biology to the clinic. Vascular Medicine . 1996
Negative Regulation of Autophagy by UBA6-BIRC6–Mediated Ubiquitination of LC3 Although the process of autophagy has been extensively studied, the mechanisms that regulate it remain insufficiently understood. The ability to manipulate autophagy is important not only for addressing fundamental biological ques...
Then we used the DAVID website to perform Gene ontology (GO) functional analysis of these genes. The biological processes of CTSB mainly contain signal transduction, immune response, inflammatory response, innate immune response, regulation of immune response, interferon-gamma-mediated signaling pathway...
While the importance of numerous protein players in these pathways has been well elucidated, the role of non-coding RNAs (ncRNAs) in the regulation of the IFN response is less well understood. Amongst the various classes of ncRNAs, micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs) are...
Renewal of the gastrointestinal epithelium involves a coordinated process of terminal differentiation and programmed cell death. Integrins have been implic... JW Lee,RL Juliano - 《Molecular Biology of the Cell》 被引量: 279发表: 2000年 Regulation of Melanogenesis through Phosphatidylinositol 3-Kinase-...
The regulation of protein function by multisite phosphorylation--a 25 year update. The phosphorylation of a protein can alter its behaviour in almost every conceivable way. These include modulation of its intrinsic biological activity, su... P Cohen - 《Trends in Biochemical Sciences》 被引量: ...
We find that ferroptosis negative regulation (FNR) signatures are closely correlated with the progression and chemoresistance of gastric cancer. FNR associated genes (GPX4, SLC7A11, and FTH1) and STAT3 are upregulated in 5-FU resistant cells and xenografts. Further evidence demonstrates that STAT3 ...
antagonistnaked cuticlewhich causes down-regulation of Dishevelled (Zeng et al., 2000;Creyghton et al., 2005). The involvement of trimeric G protein signaling in the regulation of Wnt signaling was suggested by the finding that Frizzled interacts with the Gα subunit of trimeric G proteins in...
Nevertheless, the interaction of JAK1 with PJA2 was further confirmed for the endogenous proteins (Fig. 6i). We sought to determine whether the E3 ubiquitin ligase activity of PJA2 contributes to its negative regulation of type I IFN signaling. In an orthogonal approach to our siRNA-based ...