Gene Expression RegulationModels, BiologicalReceptor Protein-Tyrosine KinasesNF‐κB‐dependent immune responses are tightly controlled so as to avoid runaway inflammation. One easy model to study the negative r
However, the regulation of adipogenesis at the posttranscriptional level has yet to be fully understood. RNA-binding proteins (RBPs) play an essential role in governing the fate of mRNA transcripts from biogenesis, stabilization, translation to RNA decay5,6. Several RBPs have been reported as ...
We find that ferroptosis negative regulation (FNR) signatures are closely correlated with the progression and chemoresistance of gastric cancer. FNR associated genes (GPX4, SLC7A11, and FTH1) and STAT3 are upregulated in 5-FU resistant cells and xenografts. Further evidence demonstrates that STAT3 ...
Synthesis and evaluation of a radioiodinated peptide probe targeting 伪v尾6 integrin for the detection of pancreatic ductal adenocarcinoma. INTRODUCTION: () remains a major cause of -related . Since significant upregulation of αvβ6 integrin has been reported in , this integrin is a promising ....
As such, we focused on uncovering the role of monomethylation on IFITM3 function and finding the PTM enzyme responsible for this process. EXPERIMENTAL PROCEDURES Plasmids, Antibodies, and Reagents Coding sequences of IFITM1, IFITM2, IFITM3, and SET7 were amplified by PCR from cDNA generated ...
(1994) Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses. J. Immunol. 153, 5802–5809. PubMed CAS Google Scholar Pruitt, J.H., Edwards, P.D., Harward, R.R.S., Seeger, J.W., Martin, T.D., et al...
The signaling pathway and its inhibitors of TNBC. Presentation of TNBC-related signaling pathways and their inhibitors. Excitatory regulation is symbolized by black arrows, red arrows stand for inhibitory effects. (The TNBC signaling pathway and its inhibitors were adapted from Fig.2in [79]) ...
Insights into protein–protein interactions (PPIs) can shed light into the molecular mechanisms of biological processes, inform about pathogenesis, and help identify disease intervention points. The prevalent experimental methods include the two-hybrid system [1,2] and co-immunoprecipitation [3,4], whi...
While the importance of numerous protein players in these pathways has been well elucidated, the role of non-coding RNAs (ncRNAs) in the regulation of the IFN response is less well understood. Amongst the various classes of ncRNAs, micro RNAs (miRNAs) and long non-coding RNAs (lncRNAs) are...
Sirtuin 1 (SIRT1) is involved in both aging and circadian-clock regulation, yet the link between the two processes in relation to SIRT1 function is not clear. Using Sirt1-deficient mice, we found that Sirt1 and Period 2 (Per2) constitute a reciprocal neg