Anatomy of a negative feedback loop: the case of IkappaBalpha. J R Soc Interface. 2015;12:0262.Fagerlund, R. et al. Anatomy of a negative feedback loop: the case of Ikappa- Balpha. J. R. Soc. Interface 12, 0262 (2015).
In contrast to negative feedback loops, positive feedback loopsamplify their initiating stimuli, in other words, they move the system away from its starting state. What is positive feedback in anatomy? In positive feedback,the body changes from the normal point and amplifies it. Examples include...
Moreover, CCN5 expressing BC cells are always ER-α positive, while CCN5 expression is lacking in HER-2/Neu positive and triple-negative BC (TNBC) cells.25,27–31 Ectopic CCN5 1Cancer Research Unit, Kansas City VA Medical Center, Kansas City, MO, USA; 2Department of Anatomy and Cell ...
Finally, large-scale recordings from the retina may allow functional identification of a large set of different ganglion cell types52, providing a basis for large-scale analyses of functional connectivity, complementing high-resolution measurements of receptive fields53 as well as anatomy-based ...
Because CCN5 is an estrogen response gene in ER-α-positive BC cells25 and present studies showed that the estradiol-treatment is able to activate CCN5 transcription in hrCCN5-treated TNBC cells (Figure 6), we conceived the possibility of a autocrine-paracrine feedback signaling loop between ...
/ 9faIbrE5saItIs; 9faIbrE`saItIs/ n [U] inflammation of the fibrous tissue of the body, esp the muscles of the back, causing severe pain and stiffness 纤维织炎; 肌风湿病. Cf 参看arthritis, rheumatism. fibula / 5fIbjUlE; `fIbjElE/ n (pl fibulae / -li:; -9li/) (anatomy 解) ou...
Chuanfei LiDepartment of Gastroenterology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, 400010, ChinaLi GanDepartment of Anatomy, and Laboratory of Neuroscience and Tissue Engineering, Basic Medical College, Chongqing Medical University, Chongqing, 400016, China...
CCN5/WISP-2 is an anti-invasive molecule and prevents breast cancer (BC) progression. However, it is not well understood how CCN5 prevents invasive phenotypes of BC cells. CCN5 protein expression is detected in estrogen receptor-α (ER-α) -positive norm
Overall, our study unveiled the underlying molecular mechanism by which miR-489 regulates an estrogen signaling pathway through a negative feedback loop and uncovered its role in both the development of and overcoming of tamoxifen resistance in breast cancers. Keywords: miR-489; breast cancer; ...